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Anthelmintic activity of plants against gastrointestinal nematodes of goats: a review

Published online by Cambridge University Press:  14 June 2019

Francianne Oliveira Santos ,
Amanda Ponce Morais Cerqueira ,
Alexsandro Branco ,
Maria José Moreira Batatinha  and
Mariana Borges Botura Open the ORCID record for Mariana Borges Botura [Opens in a new window]
Francianne Oliveira Santos
Affiliation:
Laboratório de Toxicologia, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, CEP: 44036-900, Feira de Santana, BA, Brazil
Amanda Ponce Morais Cerqueira
Affiliation:
Laboratório de Toxicologia, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, CEP: 44036-900, Feira de Santana, BA, Brazil
Alexsandro Branco
Affiliation:
Laboratório de Fitoquímica, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, CEP: 44036-900, Feira de Santana, BA, Brazil
Maria José Moreira Batatinha
Affiliation:
Laboratório de Toxicologia, Hospital de Medicina Veterinária, Universidade Federal da Bahia, Av. Ademar de Barros, 500, Ondina, CEP: 40170-110, Salvador, BA, Brazil
Mariana Borges Botura*
Affiliation:
Laboratório de Toxicologia, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, CEP: 44036-900, Feira de Santana, BA, Brazil
*
Author for correspondence: Mariana Borges Botura, E-mail: mbbotura@uefs.br
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Abstract

The gastrointestinal nematodes (GIN) stand out as an important cause of disease in small ruminant, especially on goat farm. Widespread resistance to synthetic anthelminthics has stimulated the research for alternative strategies of parasite control, including the use of medicinal plants. The present work summarizes the in vitro and in vivo studies of plants with activity against GIN of goats, focusing on the description of chemical constituents related to this effect. This review retrieved 56 scientific articles from 2008 to 2018 describing more than 100 different plant species. The most frequently investigated family was Fabaceae (30.7%). Most in vitro studies on the activity of plant extracts and fractions were carried out with of free-living stages nematodes. In vivo studies were conducted mainly with the use of plants in animal feed and generally showed lower effectiveness compared to in vitro assays. The main plant secondary metabolites associated with anthelmintic effect are condensed tannins, saponin and flavonoids. However, the studies with compounds isolated from plants and elucidation of their mechanisms of action are scarce. Herbal medicines are thought to be promising sources for the development of effective anthelmintic agents.

Keywords

Anthelminticgastrointestinal nematodesgoatsmedicinal plants
Type
Review Article
Information
Parasitology , Volume 146 , Issue 10 , September 2019 , pp. 1233 - 1246
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Copyright
Copyright © Cambridge University Press 2019 

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