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Morphological effects of arprinocid on developmental stages of Eimeria tenella and E. brunetti

Published online by Cambridge University Press:  06 April 2009

S. J. Ball
Affiliation:
Department of Biology and Biochemistry, North East London Polytechnic, Romford Road, London E15 4LZ
R. M. Pittilo
Affiliation:
E. M. Unit, Histopathology Department, The Bland Sutton Institute of Pathology, The Middlesex Hospital Medical School, London W1 P 7PN
C. C. Norton
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey KT15 3NB
L. P. Joyner
Affiliation:
Central Veterinary Laboratory, MAFF, New Haw, Weybridge, Surrey KT15 3NB

Extract

Medication of chicks with 70p.p.m. arprinoeid in the food, starting 2 days prior to inoculation with Eimeria tenella, resulted in decreased oocyst production and oocyst sporulation. The main morphological alteration seen during the development of the second-generation schizont was a reduction in the number of second-generation merozoites due to incomplete merogony, resulting in large masses of vacuolated residual cytoplasm. In places around the developing macrogamete the integrity of the parasitophorous vacuole was lost by either the host cell limiting membrane making contact with the parasite pellicle, or the disruption of one or both of these surfaces apparently brought about by the intervention of the host cell mitochondria. Thirty p.p.m. arprinocid reduced sporulation of the oocysts of E. brunetti and caused enlargement of the perinuclear space in the late merozoites and swelling of the endoplasmic reticulum around wall-forming bodies II.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1985

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References

Bergmann, V. (1970). Elektronenmikroskopische Untersuchungen zur Pathogenese der Blinddarmkokzidiose der Hühnerküken. Archiv für experimentelle Veterinär Medizin 24, 1169–84.Google Scholar
Doens-Juteau, O. & , J. (1974). Étude ultrastructurale de la paroi du macrogamete et de l'ooyste chez Eimeria tenella (Railliet et Lucet, 1891) coceidie Eimeriidae, parasite de l'intestin des poullets. Protistologica 10, 261–70.Google Scholar
Ferguson, D. J. P., Birch-Andersen, A., Hutchison, W. M. & Silm, J. Chr. (1976). Ultrastructural studies on the endogenous development of Eimeria brunetti. 1. Schizogony. Ada pathologica microbiologica Scandinavica, B 84, 401–13.Google Scholar
Ferguson, D. J. P., Birch-Andersen, A., Hutchison, W. M. & Silm, J. Chr. (1977 a). Ultrastructural studies on the endogenous development of Eimeriabrunetti. 2. Microgametogony and the microgamete. Ada pathologica microbiologica Scandinavica, B 85, 6777.Google Scholar
Ferguson, D. J. P., Birch-Andersen, A., Hutchison, W. M. & Silm, J. Chr. (1977 b). Ultrastructural studies on the endogenous development of Eimeria brunetti. 3. Macrogametogony and the macrogamete. Ada pat hologica microbiologica Scandinavica, B 85, 7888.Google Scholar
Fernando, M. A. & Stockdale, P. H. G. (1974). Fine structural changes associated with schizogony in Eimeria necatrix. Zeitschrift für Parasitenkunde 43, 105–14.CrossRefGoogle ScholarPubMed
Honnons, S., Stoebner, P. & Ambroise-Thomas, P. (1978). Disposition mitochondriale particuliere dans les cellules parasitees par Toxoplasma gondii. La Nouvelle Presse Medicate 7, 3551.Google Scholar
Jones, T. C. & Hirsch, J. G. (1972). The interaction between Toxoplasma gondii and mammalian cells. 2. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. Journal of Experimental Medicine 136, 1173–94.CrossRefGoogle Scholar
Latter, V. S. & Wilson, R. G. (1979). Factors influencing the assessment of anticoccidial activity in cell structure. Parasitology 79, 169–75.CrossRefGoogle Scholar
Long, P. L. & Jeffers, T. K. (1982). Studies on the stage of action of ionophorous antibiotics against Eimeria. Journal of Parasitology 68, 363–71.CrossRefGoogle ScholarPubMed
Long, P. L., Millard, B. J., Joyner, L. P. & Norton, C. C. (1976). A guide to laboratory techniques used in the study and diagnosis of avian coccidiosis, Folia Veterinaria Latina 6, 201–17.Google Scholar
Lücht, I. G., Millard, B. J. & Scholtyseck, E. O. (1978). Fine structural aspects of an embryo-adapted strain of Eimeria tenella in the epithelial cells of the chorio-allantoic membrane. Parasitology 76, 185–91.CrossRefGoogle ScholarPubMed
Mclaren, D. J. (1969). Observations on the fine structural changes associated with schizogony and gametogony in Eimeria tenella. Parasitology 59, 563–74.CrossRefGoogle ScholarPubMed
Mcmanus, E. C. (1980). The effect of arprinocid on the reproductive potential of a field isolate of Eimeria tenella. Journal of Parasitology 66, 926–8.CrossRefGoogle ScholarPubMed
Mcmanus, E. C., Olson, G. & Pulliam, J. D. (1980). Effects of arprinocid on developmental stages of Eimeria tenella. Journal of Parasitoiogy 66, 765–70.CrossRefGoogle ScholarPubMed
Nouyen, B. T., Stadtsbaeder, S. & Horvat, F. (1979). Macrophages infectes par Toxoplasma gondii RH. Influence in vitro du cotrimoxazole sur l'interaction mitochondries-vacuoles parasitophoriques. La Nouvelle Presse Medicale 8, 2833.Google Scholar
Pittilo, R. M. & Ball, S. J. (1979). The fine structure of the developing macrogamete of Eimeria maxima. Parasitology 79, 259–65.CrossRefGoogle ScholarPubMed
Pittilo, R. M., Ball, S. J., Joyner, L. P. & Norton, C. C. (1981). Ultrastructural changes in the macrogamete and early oocyst of Eimeria maxima resulting from drug treatment. Parasitology 83, 285–91.CrossRefGoogle ScholarPubMed
Ruff, M. D., Anderson, W. I. & Reid, W. M. (1978). Effect of the anticoccidial arprinocid on production, sporulation, and infectivity of Eimeria oocysts. Journal of Parasitology 64, 306–11.CrossRefGoogle ScholarPubMed
Scholtyseck, E., Gönnert, R. & Haberkorn, A. (1969). Die Feinstruktur der Makrogameten des Hühnercoccids Eimeria tenella. Zeitschrift für Parasitenkunde 33, 3143.Google Scholar
Sheffield, H. G. & Melton, M. L. (1968). The fine structure and reproduction of Toxoplasma gondii. Journal of Parasitology 54, 209–26.CrossRefGoogle ScholarPubMed
Wang, C. C. & Simashkevich, P. M. (1980). A comparative study of the biological activities of arprinocici and arprinocid-1-N-oxide. Molecular Biochemical Parasitology 1, 335–45.CrossRefGoogle ScholarPubMed
Wang, C. C., Simashkevich, P. M. & Fan, S. S. (1981). The mechanism of anticoccidial action of arprinocid-1-N-oxide. Journal of Parasitology 67, 137–49.CrossRefGoogle ScholarPubMed
Wang, C. C., Simashkevich, P. M. & Stotish, R. L. (1979). Mode of anticoccidial action of arprinocid. Biochemical Pharmacology 28, 2241–8.CrossRefGoogle ScholarPubMed
Wang, C. C., Tolman, R. L., Simashkevich, P. M. & Stotish, R. L. (1979). Arprinocid, an inhibitor of hypoxanthine-guanine transport. Biochemical Pharmacology 28, 2249–60.CrossRefGoogle ScholarPubMed

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