Alzate, JF, Alvarez-Barrientos, A, Gonzalez, VM and Jimenez-Ruiz, A (2006) Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X(L) expression. Apoptosis 11, 161–171.
Alzate, JF, Arias, AA, Moreno-Mateos, D, Alvarez-Barrientos, A and Jimenez-Ruiz, A (2007) Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum. Molecular and Biochemical Parasitology 152, 192–202.
Barak, E, Amin-Spector, S, Gerliak, E, Goyard, S, Holland, N and Zilberstein, D (2005) Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response. Molecular and Biochemical Parasitology 141, 99–108.
Bates, PA, Robertson, CD, Tetley, L and Coombs, GH (1992) Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology 105, 193–202.
Depledge, DP, Evans, KJ, Ivens, AC, Aziz, N, Maroof, A, Kaye, PM and Smith, DF (2009) Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. PLOS Neglected Tropical Diseases 3, e476.
Dey, R, Meneses, C, Salotra, P, Kamhawi, S, Nakhasi, HL and Duncan, R (2010) Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence. Molecular Microbiology 77, 399–414.
Hsiao, CH, Yao, C, Storlie, P, Donelson, JE and Wilson, ME (2008) The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi. Molecular and Biochemical Parasitology 157, 148–159.
Huynh, C, Sacks, DL and Andrews, NW (2006) A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. Journal of Experimental Medicine 203, 2363–2375.
Killick-Kendrick, R (1990) The life-cycle of Leishmania in the sandfly with special reference to the form infective to the vertebrate host. Annales de Parasitologie Humaine et Comparee 65(suppl. 1), 37–42.
Lahav, T, Sivam, D, Volpin, H, Ronen, M, Tsigankov, P, Green, A, Holland, N, Kuzyk, M, Borchers, C, Zilberstein, D and Myler, PJ (2011) Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania. The FASEB Journal 25, 515–525.
Lennicke, C, Rahn, J, Lichtenfels, R, Wessjohann, LA and Seliger, B (2015) Hydrogen peroxide – production, fate and role in redox signaling of tumor cells. Cell Communication and Signaling: CCS 13, 39.
Loor, G, Kondapalli, J, Schriewer, JM, Chandel, NS, Vanden Hoek, TL and Schumacker, PT (2010) Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radical Biology and Medicine 49, 1925–1936.
Marinho, HS, Real, C, Cyrne, L, Soares, H and Antunes, F (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biology 2, 535–562.
Mittra, B, Cortez, M, Haydock, A, Ramasamy, G, Myler, PJ and Andrews, NW (2013) Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. Journal of Experimental Medicine 210, 401–416.
Mittra, B, Laranjeira-Silva, MF, Perrone Bezerra de Menezes, J, Jensen, J, Michailowsky, V and Andrews, NW (2016) A trypanosomatid iron transporter that regulates mitochondrial function Is required for Leishmania amazonensis virulence. PLoS Pathogens 12, e1005340.
Mittra, B, Laranjeira-Silva, MF, Miguel, DC, Perrone Bezerra de Menezes, J and Andrews, NW (2017) The iron-dependent mitochondrial superoxide dismutase SODA promotes Leishmania virulence. Journal of Biological Chemistry 292, 12324–12338.
Murray, HW (1981) Interaction of Leishmania with a macrophage cell line. Correlation between intracellular killing and the generation of oxygen intermediates. Journal of Experimental Medicine 153, 1690–1695.
Rochette, A, Raymond, F, Ubeda, JM, Smith, M, Messier, N, Boisvert, S, Rigault, P, Corbeil, J, Ouellette, M and Papadopoulou, B (2008) Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. BMC Genomics 9, 255.
Sacks, DL and Melby, PC (2001) Animal models for the analysis of immune responses to leishmaniasis. Current Protocols in Immunology Edited By Coligan, John E. et al. Chapter 19, Unit 19 12. doi: 10.1002/0471142735.im1902s28.
Saunders, EC, Ng, WW, Kloehn, J, Chambers, JM, Ng, M and McConville, MJ (2014) Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism. PLoS Pathogens 10, e1003888.
Sereno, D and Lemesre, JL (1997). Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents. Antimicrobial Agents and Chemotherapy 41, 972–976.
Sies, H (2014). Role of metabolic H2O2 generation: redox signaling and oxidative stress. Journal of Biological Chemistry 289, 8735–8741.
Somanna, A, Mundodi, V and Gedamu, L (2002) In vitro cultivation and characterization of Leishmania chagasi amastigote-like forms. Acta Tropica 83, 37–42.
Tatapudy, S, Aloisio, F, Barber, D and Nystul, T (2017) Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Reports 18, 2105–2118.
Torres-Guerrero, E, Quintanilla-Cedillo, MR, Ruiz-Esmenjaud, J and Arenas, R (2017) Leishmaniasis: a review. F1000Research 6, 750.
Tsukagoshi, H, Busch, W and Benfey, PN (2010) Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. Cell 143, 606–616.
WHO (2010) Control of the leishmaniasis. World Health Organ Tech Rep Ser, xii-xiii, 1–186, back cover.
Williams, RA, Woods, KL, Juliano, L, Mottram, JC and Coombs, GH (2009) Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy 5, 159–172.
Wilson, ME, Andersen, KA and Britigan, BE (1994) Response of Leishmania chagasi promastigotes to oxidant stress. Infection and Immunity 62, 5133–5141.
Zhang, WW and Matlashewski, G (1997) Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2. Proceedings of the National Academy of Sciences of the USA 94, 8807–8811.
Zhang, WW, Charest, H, Ghedin, E and Matlashewski, G (1996) Identification and overexpression of the A2 amastigote-specific protein in Leishmania donovani. Molecular and Biochemical Parasitology 78, 79–90.
Zilberstein, D and Shapira, M (1994) The role of pH and temperature in the development of Leishmania parasites. Annual Review of Microbiology 48, 449–470.