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Control of Plasmodium vivax malaria by mass chemoprevention with primaquine

  • Hyon-Ok Kim (a1), Tong-Chan Ko (a1), Song-Su Kim (a1), Song-Guk Im (a1) and Yun-Nam Kim (a1)...

Abstract

In Democratic People's Republic of Korea, only Plasmodium vivax malaria is prevalent, which is divided into two forms – long incubation form and short form. Among malaria cases reported in a year, long form accounts for 69% and short form 31%. Incubation period of short form ranges from 10 to 29 days (average 17 days) and long from 5·5 to 16 months (average 8–13 months). The most relapses (90%) were reported from May to September – malaria transmission season in the country. Result from preliminary mass chemoprevention in small size of population before transmission season to find appropriate method showed high protective efficacy in two regimens – one regimen given primaquine 0·25 mg base kg−1 day−1 for 14 days (95%) and another 0·5 mg base kg−1 day−1 for 7 days (94%). During the mass chemoprevention with primaquine, some adverse effects were reported but transient. We consider that mass chemoprevention with primaquine before transmission season is of great significance in disturbing the vivax malaria transmission, in which long incubation form is predominant in countries prevailing seasonal malaria.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.

Corresponding author

Author for correspondence: Hyon-Ok Kim, E-mail: ryongnam17@yahoo.com

References

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