Hematopoietic Stem Cell Transplantation (HSCT) is standard treatment for many high risk hematologic malignancies and non-malignant diseases either as part of overall treatment or after relapse. Both autologous and allogeneic transplant numbers are increasing worldwide (Storb, 2004). The procedure for transplantation is complex, can cause intense psychological distress, and extreme social strain on the patient, family members, and friends. There are times when the psychological and social issues can be more challenging for the health care team than the medical issues. Because HSCT is an intense and distinctive experience for patients and families and has the potential to cause prolonged psychological distress unlike other experiences with oncology patients, the issues unique to this population warrant special attention (Andrykowski, Brady, Henslee-Doeney, 1994, Andrykowski, 1994).