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Use of clays using ursolic acid with anti-inflammatory activity

  • M.L. Domínguez-Patiño (a1), M. Chávez-Castillo (a2) and A. Rodríguez-Martínez (a3)

Abstract

Today the company seeks alternative natural medicine that are compatible with the body, which does not produce side effects and hang time are easily accessible and cost of those who currently have. The concern of researchers and specialists in the development of new materials is to seek, to experiment and create products that can be useful and compatible with human beings so as to obtain a curative effect without a side effect originates.

The development of pharmacologically active materials has increased in recent years. People lack access to most drugs and is therefore a need for more rapid and less expensive than current, which can be applied to cellular systems in vitro, in order to evaluate the biocompatibility of new materials. The current study seeks to experiment in a new line of research that helps health care and have a better quality of life.

The excipients in the drug are auxiliary substances that help the active ingredient is the one with the therapeutic action, can be formulated in an effective and pleasant for the patient. It is one or more substances that are incorporated into the product to facilitate its preparation, maintenance or administration. We therefore tested clay known as bentonite to serve as a vehicle for transport of an active substance (ursolic acid) [1] and some scientific studies have shown that it possesses anti-inflammatory, antibacterial, antifungal and highly cytotoxic capacity. Both materials were mixed to generate a new biomaterial that has anti-inflammatory activity. Evaluation of this model was under the inhibition of edema produced by 13-acetate-12-ortho-tetradecanoylphorbol (TPA) in mouse ear.

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1. Rojas, M.G. Antibacterial antifungal and cytotoxic activities of Distisctis Buccinatoria. Pharmaceutical Biology, 45(4), 289–294 (2007).10.1080/13880200701214847
2. Peppas, N., Langer, R., “New Challenges in Biomaterials”, Science, 263: 1715–1720, (1994).10.1126/science.8134835
3. Abraham, G.A., Cuadrado, T. R. Biomaterials and cardiovascular devices. Fed. Rev. Argent Cardiol; 26(4): 491–7 (1997).
4. Stoermer, W.B., Reproceesing single- use devices “Why does the debate continue”. Med. Ved. and Diag. Indust. 21(10): 38 (1999).

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Use of clays using ursolic acid with anti-inflammatory activity

  • M.L. Domínguez-Patiño (a1), M. Chávez-Castillo (a2) and A. Rodríguez-Martínez (a3)

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