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Transimpedance Mode CMOS Microelectrode Array For In-Vitro Neuronal Activity Recording

  • Jacob S. Wegman (a1), Amar Dwarka (a1), Matthew Holzer (a1), Whye-Kei Lye (a1), Michael L. Reed (a1), Erik Herzog (a2) and Travis N. Blalock (a2)...

Abstract

A CMOS integrated microelectrode array (IMA) utilizing a low-inpedance transimpedance input has been developed. The design uses a three-stage amplifier, including a transimpedance input stage, buffer, and multiplexor. The input stage presents a low impedance which provides bias for the neural input and maximizes the current transfer into the circuit. The amplifiers are replicated in an 8x8 array, enabling measurement of a network of 64 neurons invitro. The chip was post-processed to provide a bio-compatible gold interface between the electrodes and the neurons. Simulations and experimental results demonstrate the functionality of the new design. Additional measurements are underway to provide experimental confirmation of the system with in-vitro neurons.

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1. Wise, Kensall D., Angell, James B., and Starr, Arnold. “An Integrated-Circuit Approach to Extracellular Microelectrodes.” IEEE Transactions on Biomedical Engineering 17-3 (July 1970). pp.238–46.
2. Kolla, A., Stan, Mircea R., Herzog, Erik D., Moenter, Suzanne M.. “Integrated Planar Multimicroelectrode Array for In Vitro Recording.” IEEE Conference Record of the Thirty-First Asilomar Conference on Signals, Systems, and Computers, 1997.
3. Herzog, Erik D., Geusz, Michael E., Khalsa, Sat Bir S., Straume, Martin, Block, Gene D.. “Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates.” Brain Research 757-2 (1997). pp.285–90.
4. Dwarka, A. “New Design of an Integrated Microelectrode Array for In Vitro Neural Recording.” Master's Thesis. University of Virginia, 2002.
5. Razavi, Behzad. Design of Analog CMOS Integrated Systems. Boston, MA: McGraw-Hill, 2001.

Transimpedance Mode CMOS Microelectrode Array For In-Vitro Neuronal Activity Recording

  • Jacob S. Wegman (a1), Amar Dwarka (a1), Matthew Holzer (a1), Whye-Kei Lye (a1), Michael L. Reed (a1), Erik Herzog (a2) and Travis N. Blalock (a2)...

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