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Time Interval and Continuous Testing of Stimuli Responsive Hydrogels

  • Jeffrey S. Bates (a1) and Jules J. Magda (a2)

Abstract

Researchers have investigated hydrogels as potential materials for biological monitoring. Hydrogel compositions have been designed to respond to changes in temperature, pH, glucose concentration and ionic strength concentration. Hydrogels designed to respond to changes in environmental conditions have demonstrated their ability to respond via a swelling or shrinking action. This swelling behavior can be exploited using a variety of signal transduction methods. While this technology shows promise, the degradation of hydrogel materials has not yet been characterized with respect to the shelf life of hydrogel samples or to their use in continuous testing. A series of experiments were performed to test hydrogels stored for extended periods of time then subjected to oscillatory testing, and the results have been analyzed to determine whether hydrogels can be used for extended periods of time for biological sensing applications.

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1. De, S. K., Aluru, N. R., Johnson, B., Crone, W. C., Beebe, D. J., Moore, J., Equilibrium swelling and kinetics of pH-responsive hydrogels: models, experiments and simulations, Journal of Microelectromechanical Systems 11 (2002) 544555.
2. Bienes, P. W., Klosterkamp, I., Menges, B., Jonas, U., Knoll, W., Responsive thin hydrogel layers from photo-cross-linkable poly (N-isopropylacrylamide) terpolymers, Langmuir 23 (2007) 22312238.
3. Liu, M., Guo, T., Preparation and swelling properties of crosslinked sodium polyacrylate, Journal of Applied Polymer Science 82 (2001) 15151520.
4. Kuckling, D., Hoffman, J., Plotner, M., Ferse, D., Kretschmer, K., Adler, H. P., Arndt, K., Reichelt, R., Photo cross-linkable poly(N-isopropylacrylamide) copolymers III: micro-fabricated temperature responsive hydrogels, Polymer 44 (2003) 44554462.
5. Shin, J., Braun, P. V., Lee, W., Fast responsive photonic crystal pH sensor based on template photo-polymerized hydrogel inverse opal, Sensors and Actuators B: Chemical 150 (2010) 183190.
6. Iwata, T., Suzuki, K., Amaya, N., Higuchi, H., Masunaga, H., Sasaki, S., Kikuchi, H., Control of cross-linking polymerization kinetics and polymer aggregated structure in polymer-stabilized liquid crystalline blue phases, Macromolecules 42 (2009) 20022008.
7. Galeav, I. Y., Mattiason, B., Smart polymers and what they could do in biotechnology and medicine, Trends in Biotechnology 17 (1999) 335340.
8. Bates, J.S., Cho, S.H., Tathireddy, P., Rieth, L.W., Magda, J.J., Smart Hydrogels Designed for Used in Microfabricated Sensor Arrays, MRS Proceedings 1570 (2013) 16
9. Lin, G., Chang, S., Kuo, C.-H., Magda, J., Solzbacher, F., Free swelling and confined smart hydrogels for applications in chemomechanical sensors for physiological monitoring, Sensors and Actuators B: Chemical 136 (2009) 186195.
10. Schulz, V., Guenther, M., Gerlach, G., Magda, J. J., Tathireddy, P., Rieth, L., Solzbacher, F., In-vitro investigations of a pH- and ionic-strength-responsive polyelectrolyte hydrogel using a piezoresistive microsensor, Smart Struct Mater Nondestruct Eval Health Monitor Diagn 7827 (2009) 116.
11. Gerlach, G., Guenther, M., Sorber, J., Suchanek, G., Chemical and pH sensors based on the swelling behavior of hydrogels, Sensors and Actuators B 111 (2005) 555561.

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