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Tailored Viscosity Reduction in Aqueous Hydroxypropylcellulose Solutions

Published online by Cambridge University Press:  21 February 2011

Victoria A. Prevysh ,
Richard J. Spontak  and
Saad A. Khan
Victoria A. Prevysh
Affiliation:
Department of Meterials Science & Engineering, N. Carolina State University, Raleigh NC 27695
Richard J. Spontak
Affiliation:
Department of Meterials Science & Engineering, N. Carolina State University, Raleigh NC 27695
Saad A. Khan
Affiliation:
Department of Chemical Engineering, N. Carolina State University, Raleigh NC 27695
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Abstract

Polysaccharides, including cellulosic derivatives such as hydroxypropylcellulose (HPC), are used extensively in the pharmaceutical industry due to their biocompatibility and self-organization properties. While drug delivery vehicles employing, for instance, aqueous polysaccharide gels are desirable, production of such gels can be hindered by tremendously high solution viscosity. In this work, we describe a novel means by which to reduce the viscosity and enhance the solubility of aqueous HPC. Here, the efficacy of several additives which promote HPC viscosity reduction through molecular salting-in is examined by dynamic rheology and light/electron microscopy.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 137
Copyright
Copyright © Materials Research Society 1995

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