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Synchrotron Infrared Microspectroscopy for Assessment of Mutagenicity of Metal Implants

Published online by Cambridge University Press:  15 February 2011

Miqin Zhang ,
Hoi-Ying N. Holman ,
Mauro Ferrari  and
Jennie C. Hunter-Cevera
Miqin Zhang
Affiliation:
Dept. of Materials Science. and Mineral Eng., University of California, Berkeley, CA 94720
Hoi-Ying N. Holman
Affiliation:
Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720
Mauro Ferrari
Affiliation:
Dept. of Materials Science. and Mineral Eng., University of California, Berkeley, CA 94720
Jennie C. Hunter-Cevera
Affiliation:
Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720
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Abstract

A major concern in the development and implementation of metal implants for the clinical use is the assessment of material-induced mutagenesis. In this study we used synchrotron microspectroscopy in the mid-infrared region (4000-400 cm1 ) to non-invasively assess the in situ human cell responses to metal surfaces. Specifically we examined the subtle genetic aberrations of cells as they responded to a range of metals commonly used in metal prosthetic devices. Relative band intensities and band intensity ratios for functional groups of biomolecules that are inherent to the experimental system were examined. The molecular components of the biomolecules as they were perturbed by the interactions with metals were investigated. These results demonstrate the potential use of synchrotron FTIR microspectroscopy to screen the mutagenicity of metal implants.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 163
Copyright
Copyright © Materials Research Society 1999

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