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Spatial Marking and Quantitative Counting Cell Membrane αIIbβ3 Integrin in Single Cells via Peptide-Au Cluster Probes

  • Lina Zhao (a1) and Xueyun Gao (a1)

Abstract

We propose a theoretical designed peptide-Au cluster probe and realize spatially marking and quantitatively counting αIIbβ3 integrin via this novel nanoprobe. On single cell level, we find the number of αIIbβ3 integrin ranges from 5.75 to 9.11×10-17 mol for the heteroexpression of individual cells. Because the variation of proteins (including integrin and other biomarkers) on single cell has a tight correlation with many serious human diseases, our quantifying protein method on a single cell level is helpful for estimating the disease progression for diagnosis and detecting the drug response for therapy.

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