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Small Molecule Diffusion and Solubility in Adhesives Used for Transdermal Drug Delivery: Infrared-Attenuated Total Reflectance (IR-ATR) Studies.

Published online by Cambridge University Press:  15 March 2011

Adam S. Cantor
Adam S. Cantor*
Affiliation:
M Drug Delivery Systems Division, 3M Center, Building 260-4N-12, St. Paul, MN 55144-1000, U.S.A
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Abstract

A key factor in designing a drug-in-adhesive transdermal drug delivery system is to understand the rate at which the drug and small-molecule excipients can diffuse in the adhesive matrix. The solubility of these components in the adhesive matrix is also of great importance. Results will be presented discussing the use of infrared-attenuated total reflectance (IR-ATR) spectroscopy as a method to measure both diffusion and solubility of small molecules in adhesives. In this method, the donor layer is either a doped adhesive or a free liquid that is placed in contact with a receptor layer which is an undoped adhesive in contact with an IR-ATR crystal. The IR-ATR crystal detects as a function of time any molecules that diffuse from the donor layer into and through the receptor layer.

Examples will be discussed of several different experiments that can be performed with this technique. Diffusion coefficients are presented here for testosterone and terpineol in an isooctyl acrylate based adhesive using a doped adhesive donor layer. Diffusion and solubility of liquids in several adhesives has been determined using the experiment where a free liquid is used as the donor. Solubility and diffusion coefficients determined using an oversaturated doped layer containing dispersed, as well as dissolved solute, are presented here for testosterone and for progesterone. Finally diffusion from a doped layer of one adhesive to an undoped layer of a different adhesive was performed as a partition measurement. The parameters that can be extracted from each of these experiments, as well as the limitations of each type of experiment will be discussed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 662: Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering , 2000 , NN4.4
Copyright
Copyright © Materials Research Society 2001

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References

1. Schlotter, N. E., Furlan, P. Y., Small molecule diffusion in polyolefins monitored using the infrared evanescent field, Vibrational Spectroscopy, 3 (1992) 147–153.Google Scholar
2. Fieldson, G. T., Barbari, T. A., The use of FTi.r.-a.t.r. spectroscopy to characterize penetrant diffusion in polymers, Polymer, 34(9) (1993) 1146–1153.Google Scholar
3. Fieldson, G. T., Barbari, T. A., Analysis of diffusion in polymers using attenuated total reflectance Fourier-transform infrared spectroscopy, Polym. Mater. Sci. Eng., 71 (1994) 150–151.Google Scholar
4. Wurster, D. E., Buraphacheep, V., Patel, J. M., The determination of diffusion coefficients in semisolids by Fourier transform infrared (FT-IR) spectroscopy, Pharm. Res., 10(4) (1993) 616–620.Google Scholar
5. Alsten, J. G. van, Lustig, S. R., Polymer mutual diffusion measurements using infrared ATR spectroscopy, Macromolecules, 25 (1992) 5069–5073.Google Scholar
6. Garbe, J. E., Northey, P. J., Peterson, T. A., U.S. Patent 5,688,523, 1997.Google Scholar
7. Cantor, A. S., Drug and excipient diffusion and solubility in acrylate adhesives measured by IR/ATR spectroscopy, J. Controlled Release, 61 (1999) 219–231.Google Scholar
8. Comyn, J., Polymer Permeability, in: J. Comyn, (Ed.), Introduction to Polymer Permeability and the Mathematics of Diffusion, Elsevier Applied Science, London, 1985, p 9.Google Scholar
9. CRC Standard Math Tables, Beyer, W. H. (Ed.), CRC Press, Boca Raton, FL, 1979, 25th ed., p 415.Google Scholar
10. Cantor, A. S., Proceeedings of the 27th International Symposium on Controlled Release of Bioactive Materials, Paris, France; Controlled Release Society: Chicago, IL, 2000; Abstract 7403.Google Scholar