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A PVA-PCL Bioglass Composite with Potential Implications for Osteochondral Tissue Engineering

Published online by Cambridge University Press:  31 January 2011

Prabha D Nair ,
Lakshmi M Mukundan ,
Remya Nirmal  and
Neethu Mohan
Prabha D Nair
Affiliation:
pdnair49@gmail.com
Lakshmi M Mukundan
Affiliation:
lakshmi_mukundan@yahoo.co.in, SCTIMST, DTERT, Trivandrum, India
Remya Nirmal
Affiliation:
remyanirmal@yahoo.co.in, SCTIMST, DTERT, Trivandrum, India
Neethu Mohan
Affiliation:
biochemneethu@gmail.com, SCTIMST, DTERT, Trivandrum, India
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Abstract

A bioglass of composition SiO2 (67.12 mol%), CaO (28.5 mol%), and P2O5 (4.38%) was synthesized and stabilized by a novel technique using ethanol. Bioactive glasses have a wide range of application in the field of biomaterials promoting bone bonding as well as bonding to soft tissue. Earlier our lab developed a novel PVA-PCL semi IPN porous and 3D scaffold that was found to favor chondrogenesis. In the present study, a composite of this polymer and bioglass is prepared by an emulsion freeze-drying process, as a porous 3 dimensional scaffold. The scaffolds were characterized for their physiochemical properties and ability to support cartilage tissue regeneration. The composite scaffolds were observed to be non-cytotoxic. The chondrocytes cells cultured in vitro for a month on the composite scaffolds regenerate cartilaginous tissue, secreting GAGs and collagen in amounts nearly comparable to the amounts on the control PVA-PCL scaffold. The composite scaffold is also biomimetic and bioactive and favors mineralization by forming a hydroxycarbonate apatite layer, when immersed in simulated body fluid for a 14 day period. The PVA-PCL-bioglass composite is hence expected to have potential implications as a scaffold for osteochondral tissue engineering.

Keywords

biomimetic (chemical reaction)bonetissue
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1235: Symposium RR – Engineering Biomaterials for Regenerative Medicine , 2009 , 1235-RR03-28
Copyright
Copyright © Materials Research Society 2010

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