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Preparation and properties of phenytoin silica complex nanoparticles

Published online by Cambridge University Press:  10 February 2011

H. Goto ,
T. Isobe  and
M. Senna
H. Goto
Affiliation:
Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223, Japan.
T. Isobe
Affiliation:
Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223, Japan.
M. Senna
Affiliation:
Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223, Japan.
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Abstract

A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was added during hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS). The average size of the composite primary particles after in situ recrystallization of PT and gelation of silica was 2–3nm. The extent of hydrogen bond (HB) in PT was reduced after the complex formation (CF), while many PT molecules were attached by HB on the surface of silica gel. The apparent solubility to ethanol decreased to 29%∼18% by CF. The firstorder rate constant of dissolution of PT into H20 increased by CF up to 40 times. Addition of acrylamide also enhanced the dissolution rate. Mechanisms of faster dissolution were discussed in terms of the hydrogen bond reformation and microstructure.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 501: Symposium FF – Surface Controlled Nanoscale Materials for High-Added… , 1997 , 321
Copyright
Copyright © Materials Research Society 1998

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References

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