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Polymerization in Inverse Microemulsion: An Effective Tool to Produce Biodegradable and non Biodegradable Nanoparticles

Published online by Cambridge University Press:  15 March 2011

F. Lebon ,
C. Grandfils ,
R. Jérôme ,
I. Barakat  and
L. Sartore
F. Lebon
Affiliation:
Dip. Scienze Biomediche e Biotecnologie, Univ. di Brescia, Brescia, Italy Ist. Nazionale di Fisica della Materia (INFM), Brescia, Italy
C. Grandfils
Affiliation:
Interfacultary Biomaterial Centre, University of Liège, Belgium
R. Jérôme
Affiliation:
Interfacultary Biomaterial Centre, University of Liège, Belgium CERM (Center for Education & Research on Macromolecules), University of Liège, Belgium
I. Barakat
Affiliation:
Interfacultary Biomaterial Centre, University of Liège, Belgium
L. Sartore
Affiliation:
Dip. di Chimica e Fisica per l'Ingegneria e i Materiali, Università di Brescia, Brescia, Italy
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Abstract

Potential of polymerization in inverse microemulsions has been illustrated by the preparation of crosslinked nanoparticles with functional groups on the surface. Nonbiodegradable polyacrylamide nanoparticles have been prepared, with the purpose to use these stable monodisperse lattices as enzymatic reactors and in diagnostic applications. Their size is in the 50 to 90 nm range and they contain a model enzyme (alkaline phosphatase) immobilized. In another example, monodisperse biodegradable nanoparticles of polyamidoamines with a size from 90 to 130 nm have been prepared. They are envisioned for intravenous administration because of a low content of non-metabolized material and absence of toxicity.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 703: Symposia U/V – Nanophase and Nanocomposite Materials IV , 2001 , V2.9
Copyright
Copyright © Materials Research Society 2002

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References

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