Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-24T08:24:04.884Z Has data issue: false hasContentIssue false
  • English
  • Français

Physiological Evaluation of Fluorocarbon Emulsions with Notes on F-Decalin and Pulmonary Inflation in the Rabbit

Published online by Cambridge University Press:  26 February 2011

Leland C. Clark Jr. ,
Richard E. Hoffmann ,
Robert B. Spokane  and
Pat E. Winston
Leland C. Clark Jr.
Affiliation:
Children's Hospital Research Foundation, Department of Neurophysiology, Elland and Bethesda Avenues, Cincinnati, OH 45229-2899
Richard E. Hoffmann
Affiliation:
Children's Hospital Research Foundation, Department of Neurophysiology, Elland and Bethesda Avenues, Cincinnati, OH 45229-2899
Robert B. Spokane
Affiliation:
Children's Hospital Research Foundation, Department of Neurophysiology, Elland and Bethesda Avenues, Cincinnati, OH 45229-2899
Pat E. Winston
Affiliation:
Children's Hospital Research Foundation, Department of Neurophysiology, Elland and Bethesda Avenues, Cincinnati, OH 45229-2899
Get access

Abstract

Continuing refinement of fluorocarbon blood substitutes depends upon perfection and application of methods to monitor oxygen transport in living animals. Methods involving chronic catheterization, electrode implantation and tissue sampling yield valuable basic information in animal experiments. The importance of blood lactate in assessing the adequacy of fluorocarbon oxygen transport is reported here. The preliminary observation of microbubble blockade in the pulmonary capillaries in rabbits receiving F-decalin (PP5) emulsion, resulting in lungs which remain noncollapsible for at least 79 days is also reported.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 129
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Clark, L.C. Jr., Misrahy, G., Fox, R.P., J.Appl. Physiol. 13, 85 (1958).CrossRefGoogle Scholar
2. Clark, L.C. Jr., Spokane, R.B., Hoffmann, R.E., Sudan, R., Homan, M.M., Maloney, A.C., Stroup, T.L., Winston, P.E., Biomater. Artif. Cells Artif. Organs, In press (1987).Google Scholar
3. Weil, M.H., Leavy, J.A., Rackow, E.C., Halfman, C.J., Bruno, S.J., Clin. Chem. 32, 2175 (1986).Google Scholar
4. Clark, L.C. Jr., Clark, E.W., in Oxygen Transport To Tissue, ed. Bicher, H.I. and Bruley, D.F. (Plenum NY, 1973), p. 127.Google Scholar
5. Sloviter, H.A., Yamada, H., Ogoshi, S., Fed. Proc. 29 1755 (1970).Google Scholar
6. Geyer, R.P., Fed. Proc. 29, 1758 (1970).Google Scholar
7. Clark, L.C. Jr., Becattini, F., Kaplan, S., Ala. J. Med. Sci. 9, 16 (1972).Google Scholar