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Orthopedic implants from bioactive rosette nanotubes/poly(2-hydroxyethyl methacrylate)/nano-hydroxyapatite composites

Published online by Cambridge University Press:  18 April 2012

Linlin Sun ,
Lijie Zhang ,
Usha D. Hemraz ,
Hicham Fenniri  and
Thomas J. Webster
Linlin Sun
Affiliation:
School of Engineering, Brown University, 182 Hope Street, Providence, RI 02912 USA
Lijie Zhang
Affiliation:
Department of Mechanical and Aerospace Engineering, George Washington University, 801 22nd Street, Washington, DC, USA
Usha D. Hemraz
Affiliation:
National Institute for Nanotechnology and Departments of Chemistry and Biomedical Engineering, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada.
Hicham Fenniri*
Affiliation:
National Institute for Nanotechnology and Departments of Chemistry and Biomedical Engineering, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada.
Thomas J. Webster*
Affiliation:
School of Engineering, Brown University, 182 Hope Street, Providence, RI 02912 USA Department of Orthopaedics, Brown University, 593 Eddy Street, Providence, RI 02903 USA
*
*Corresponding author: E-mail: thomas_webster@brown.edu, hicham.fenniri@ualberta.ca
*Corresponding author: E-mail: thomas_webster@brown.edu, hicham.fenniri@ualberta.ca
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Abstract

With multifunctionality and nanoscale dimensions, self-assembled rosette nanotubes (RNTs) exhibit unique biological and mechanical properties, making them promising to serve as a new generation of implants. Synthetic twin G^C base features the hydrogen bonding arrays of both guanine and cytosine and has the ability to self-organize spontaneously into nanotubes with a 3.5 nm outer diameter, a 1.1 nm inner channel running the length of the nanotube which can reach several micrometers in length. In this study, a twin G^C motif functionalized with an aminobutyl side chain (referred to as TBL) was synthesized, assembled into bioactive RNTs and used along with poly(2-hydroxyethyl methacrylate) (pHEMA) and hydroxyapatite (HA) nanoparticles to prepare RNTs/HA/pHEMA composites for orthopedic applications. The properties of these composites was investigated, notably the solidification process, surface morphology, mechanical properties, and cytocompatibility properties. The RNTs assembled from TBL and HA nanoparticles were found to be effective towards increasing the bioactivity of the composites thus establishing the potential of TBL/HA/pHEMA composites as very promising injectable orthopedic implant materials.

Keywords

self-assemblynanostructurepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1417: Symposium KK – Biomaterials for Tissue Regeneration , 2012 , mrsf11-1417-kk03-35
Copyright
Copyright © Materials Research Society 2012

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References

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