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Nucleation and growth of polymorphs of barbital on chemically modified surfaces in microfluidic channels

Published online by Cambridge University Press:  26 February 2011

John C. MacDonald ,
Kasim Biyikli ,
Branko Zugic ,
Garrett Ebersole  and
Joshua Allor
John C. MacDonald
Affiliation:
jcm@wpi.edu, Worcester Polytechnic Institute, Department of Chemistry & Biochemistry, 100 Institute Rd., Worcester, MA, 01609-2280, United States, 508 831-5240, 508 831-5240
Kasim Biyikli
Affiliation:
biyiklik@wpi.edu, Worcester Polytechnic Institute, Department of Chemistry & Biochemistry, United States
Branko Zugic
Affiliation:
zugicb@wpi.edu, Worcester Polytechnic Institute, Department of Chemistry & Biochemistry, United States
Garrett Ebersole
Affiliation:
rewirez@wpi.edu, Worcester Polytechnic Institute, Department of Chemistry & Biochemistry, United States
Joshua Allor
Affiliation:
wents@wpi.edu, Worcester Polytechnic Institute, Department of Chemistry & Biochemistry, United States
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Abstract

Crystallization experiments have been carried out in microfluidic devices to screen for polymorphs by crystallization on a range of surfaces. These devices consist of PDMS (polydimethylsiloxane) patterned with microchannels and then bonded to self-assembled monolayers (SAMs) of organic molecules on gold substrates. Barbital was crystallized in microchannels over five different SAMs functionalized with polar and nonpolar organic groups. Growth of polymorphs was examined under thermodynamic conditions from solutions at room temperature and under kinetic conditions by rapid cooling. The results of these experiments and the influence of chemically modified surfaces in microchannels in controlling polymorphism are discussed.

Keywords

crystal growthself-assemblynucleation & growth
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 901: Symposium R – Assembly at the Nanoscale – Toward Functional Nanostructured Materials , 2005 , 0901-Ra07-04
Copyright
Copyright © Materials Research Society 2006

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