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Near Infrared Tunable Gold Nanoparticles for Low Power Laser Ablation of Esophageal Adenocarcinoma

  • Guandong Zhang (a1), Jacek Jasinski (a2), Dhruvinkumar Patel (a1), Kurtis James (a1), Xinghua Sun (a1) and Andre M. Gobin (a1)...

Abstract

Gold nanoparticles (GNPs) with precisely controlled near infrared (NIR) absorption were synthesized by one-step reaction of chloroauric acid and sodium thiosulfate. The NIR absorption wavelengths and average particle size increase with increasing molar ratio of HAuCl4/Na2S2O3. The as-synthesized GNPs consist of different shape and size, including small spherical gold colloids and larger non-spherical gold crystals. The GNPs with good chemical and optical stability only form in a suitable range of the HAuCl4/Na2S2O3 molar ratio. High molar ratio of HAuCl4/Na2S2O3 reduces GNPs stability due to Ostwald ripening. Chitosan coating improves particle stability and allows these GNPs effective ablation for esophageal adenocarcinoma under low power NIR laser radiation.

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Near Infrared Tunable Gold Nanoparticles for Low Power Laser Ablation of Esophageal Adenocarcinoma

  • Guandong Zhang (a1), Jacek Jasinski (a2), Dhruvinkumar Patel (a1), Kurtis James (a1), Xinghua Sun (a1) and Andre M. Gobin (a1)...

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