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Nanocrystalline Apatites for Bone Reconstruction

Published online by Cambridge University Press:  10 February 2011

S. Casalbou ,
V. Midy ,
A. Tofighi ,
D. Lee ,
M. Dard  and
C. Rey
S. Casalbou
Affiliation:
INPT-ENSCT, CIRIMAT, UMR CNRS 5..., Laboratoire Interfaces et Matériaux, 38 rue des 36 Ponts, 31400 Toulouse, France
V. Midy
Affiliation:
INPT-ENSCT, CIRIMAT, UMR CNRS 5..., Laboratoire Interfaces et Matériaux, 38 rue des 36 Ponts, 31400 Toulouse, France
A. Tofighi
Affiliation:
Etex Corporation, 38 Sidney street, Cambridge, MA 02139, USA
D. Lee
Affiliation:
Etex Corporation, 38 Sidney street, Cambridge, MA 02139, USA
M. Dard
Affiliation:
Merck Biomaterial, GmbH, Frankfurter Strasse, 250. 64271 Darmstadt, Germany
C. Rey
Affiliation:
INPT-ENSCT, CIRIMAT, UMR CNRS 5..., Laboratoire Interfaces et Matériaux, 38 rue des 36 Ponts, 31400 Toulouse, France
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Abstract

Poorly crystalline apatites (PCA) are characterized by a non-stoichiometric composition, a high specific surface area and the existence of labile, non-apatitic environments detected by spectroscopic techniques. These environments have been shown to belong mainly to an hydrated layer at the surface of the crystals and determine their surface and bulk reactivity. PCA can be easily synthesized in aqueous media and the amount of labile, non-apatitic environments can be modulated by using apatites at different maturation stage. PCA can adsorb many active proteins or drugs, Growth factors (FGF-2, for example), were strongly bound and remained mostly attached to the surface. Several mineral ions which have been shown to have a biological activity such as strontium, can also be trapped at the surface or into the lattice of poorly crystalline apatites. Due to their reactivity, PCA cannot be shaped easily into materials, however, they have the ability to agglomerate irreversibly into solid body at low temperature. These low temperature ceramics show a variable amount of pores (30 to 60 %) and pore size (5 to 25 nm) in which organic components can be trapped and are released only by the dissolution of the ceramic.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 39
Copyright
Copyright © Materials Research Society 2000

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