Skip to main content Accessibility help
×
Home

Molecular Imprinted Hydrogels in Drug Delivery Applications

  • Jeffrey S. Bates (a1), Luke R. Whitson (a1), Kelan M. Albertson (a1), Nathan S. Hickerson (a1), Patrick E. Nichols (a1), Bethany E. Larson (a1) and Taylor D. Sparks (a1)...

Abstract

Molecular imprinting is the process by which molecules are imprinted into the matrix of a material through non-covalent bonding, including hydrogen bonding and van der Waals interactions. In this study hydrogels were imprinted with glaucoma medication with the purpose of creating a reusable ocular drug delivery device with reversible binding sites. The material was synthesized and tested with UV-Vis spectroscopy to determine the concentration of the released drug after twelve hours in distilled water. Modifications were made to the polymer to explore methods required for the proper delivery of the drug over an adequate period of time.

Copyright

References

Hide All
1. Bates, J., Magda, J., pH-Responsive Hydrogels and their Applications in Chemomechanical Sensors, ScienceJet 4 (2014) 128.
2. West, J.L., Hubbell, J.A., Photopolymerized hydrogel materials for drug delivery applications, Reactive Polymers, 25 (1995) 139147.
3. Cunliffe, D., Kirby, A., Alexander, C., Molecularly imprinted drug delivery systems, Advanced Drug Delivery Reviews, 57 (2005) 18361853.
4. Herber, S., Bomer, J., Olthius, W., Bergveld, P., van den Berg, A., A miniaturized carbon dioxide gas sensor based on sensing of pH-sensitive hydrogel swelling with a pressure sensor, Biomedical Microdevices, 7 3 (2005) 197204.
5. Bates, J., Magda, J., Storage and Operational Stability of pH-Responsive Hydrogels, Global Journal of Science Frontier Research, 14 (2014) 6.
6. Bates, J., Magda, J., Chemomechanical pH Sensor Response Time and its Dependence on Hydrogel Thickness, Journal of Chemistry and Biochemistry (2015).
7. Bates, J., Tathireddy, P., Buetefisch, S., Magda, J., An Improved Design for Chemomechanical Sensors: The “Boss” Sensor, Chemosensors (2013).
8. Ciolino, J.B., Hoare, T.R., Iwata, N.G., Behlau, I., Dohlman, C.H., Langer, R., Kohane, D. S. A drug-eluting contact lens, Investigative Ophthalmology and Visual Science, 50 7, (2009) 33463352.
9. Gulsen, D., Chauhan, A., Ophthalmic drug delivery through contact lenses, Investigative Ophthalmology and Visual Science, 45 7 (2004) 23422347.
10. Hu, X., Hao, L., Wang, H., Yang, H., Zhang, G., Wang, W., Zhang, X., Hydrogel contact lens for extended delivery of ophthalmic drugs, International Journal of Polymer Science, (2011) 19.
11. Kearns, V.R., Williams, R.L., Drug delivery systems for the eye, Expert Review of Medical Devices, 6 3 (2009) 277314.
12. Lorenzo, C.A., Hiritani, H., Amoza, J.L.G., Pacheco, R.M., Souto, C., Concheiro, A., Soft contact lenses capable of sustained delivery of timolol, Journal of Pharmaceutical Sciences, 91 10 (2002) 21822192.
13. Venkatesh, S., Saha, J., Pass, S., Byrne, M.E., Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 69 (2008) 852860.
14. Xinming, L., Yingde, C., Lloyd, A.W., Mikhalovsky, S.V., Sandeman, S.R., Howel, C.A., Liewen, L., Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review, Contact Lens and Anterior Eye, 31 (2008) 5764.
15. Alexander, C.L., Miller, S.J., Abel, S.R. Prostaglandin analog treatment of glaucoma and ocular hypertension, The Annals of Pharmacotherapy, 36 (2002) 504511.
16. Byrne, M.E., Park, K., Peppas, N.A., Molecular imprinting within hydrogels, Advanced Drug Delivery Reviews, 54 (2001) 149161.
17. Hillberg, A.L., Brain, K.R. Allender, C.J., Molecular imprinter polymer sensors: Implications for therapeutics, Advanced Drug Delivery Reviews, 57 (2005) 18751889.
18. Lorenzo, C.A., Concheiro, A., Molecularly imprinted polymers for drug delivery, Journal of Chromatography B, 801 (2004) 231245.
19. Stringer, R.C., Gangopadhyay, S., Grant, S.A., Comparison of molecular imprinted particles prepared using precipitation polymerization in water and chloroform for fluorescent detection of nitroaromatics, Analytical Chimica Acta, 703 (2011) 239244.
20. Vasapollo, G., Del Sol, R., Mergola, L., Lazzoi, M.R., Scardino, A., Scorrano, S., Mele, G., Molecularly imprinted polymers: present and future prospective, International Journal of Molecular Science, 12 (2011) 59085945.
21. Hiratani, H., Lorenzo, C.A., The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems, Biomaterials, 25 (2004) 11051113.
22. Sato, S., Kitagawa, S., Nakajima, M., Shimada, K., Honda, A., Miyazaki, H., Assessment of tear concentrations on therapeutic drug monitoring, Pharmaceutical Research, 18 4 (2001) 500509.

Keywords

Molecular Imprinted Hydrogels in Drug Delivery Applications

  • Jeffrey S. Bates (a1), Luke R. Whitson (a1), Kelan M. Albertson (a1), Nathan S. Hickerson (a1), Patrick E. Nichols (a1), Bethany E. Larson (a1) and Taylor D. Sparks (a1)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed