Skip to main content Accessibility help
×
Home

Modeling receptor-mediated endocytosis via mechanics of cell adhesion

  • Wendong Shi (a1), Huajian Gao (a2) and Lambert Ben Freund (a3)

Abstract

A mathematical model describing how a cell membrane with diffusive mobile receptors wraps around a ligand coated cylindrical or spherical particle has been recently developed to model particle size effects in receptor mediated endocytosis. The model predicted an optimal particle size for the smallest wrapping time, as well as a minimum and a maximum particle size for successful wrapping. The results showed that particles in the size range of tens to hundreds of nanometers can enter cells even in the absence of clathrin or caveolin coats. Here we report some further progresses on modeling a spontaneous membrane curvature induced by clathrin or caveolin coats at the inner membrane leaflet as well as simultaneous entry of many particles into cells. It is found that a spontaneous membrane curvature narrows the particle size range for successful wrapping and there exists an optimal particle density for maximum particle adsorptivity.

Copyright

References

Hide All
1 Gao, H. J., Shi, W. D. and Freund, L. B., Proc. Nat. Acad. Sci. 102, 94699474 (2005)
2 Saltzman, W. M., Drug Delivery: Engineering Principles for Drug therapy (Oxford University, Oxford, 2001).
3 Davis, S. S., Trends Biotechnol. 15, 217224 (1997)
4 Pantarotto, D., Briand, J., Prato, M. and Bianco, A., Chem. Commun. 16–17 (2004)
5 Pantarotto, D., Singh, R., McCarthy, D., Erhardt, M., Briand, J., Prato, M., Kostarelos, K. and Bianco, A., Angew. Chem. Int. Ed. 43, 52425246 (2004)
6 Kam, N. W. S., Jessop, T. C., Wender, P. A. and Dai, H. J., J. Am. Chem. Soc. 126, 68506851 (2004)
7 Kam, N. W. S., O'Connell, M., Wisdom, J. A. and Dai, H. J., Proc. Nat. Acad. Sci. 102, 1160011605 (2005)
8 Warheit, D. B., Laurence, B. R., Reed, K. L., Roach, D. H., Reynolds, G. A. M. and Webb, T. R., Toxicol. Sci. 77, 117125 (2004)
9 Lam, C. W., James, J. T., McCluskey, R. and Hunter, R. L., Toxicol. Sci. 77, 126134 (2004)
10 Cann, A. J., Principles of Molecular Virology, 2nd ed. (Academic Press, San Diego, 1997).
11 Levy, J. A., Fraenkel-Conrat, H. F. and Owens, R. A., Virology, 3rd ed. (Prentice Hall, New York, 1994).
12 Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. and Watson, J. D., Molecular Biology of the Cell, 3rd ed. (Garland Science, New York, 1994).
13 Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P., Molecular Biology of the Cell, 4th ed. (Garland Science, New York, 2002).
14 Kirchhausen, T., Cell, 109, 413416 (2002)
15 Sieczkarski, S. B. and Whittaker, G. R., J. Virol. 76, 1045510464 (2002)
16 Lakadamyali, M., Rust, M. J. and Zhuang, X., Microbes Infect. 6, 929936(2004)
17 Desai, M. P., Labhasetwar, V., Walter, E., Levy, R. J. and Amidon, G. L., Pharm. Res. 14, 15681573 (1997)
18 Prabha, S., Zhou, W. Z., Panyam, J. and Labhasetwar, V., Int. J. Pharm. 244 105115 (2002)
19 Aoyama, Y., Kanamori, T., Nakai, T., Sasaki, T., Horiuchi, S., Sando, S. and Niidome, T., J. Am. Chem. Soc. 125, 34553457 (2003)
20 Nakai, T., Kanamori, T., Sando, S. and Aoyama, Y., J. Am. Chem. Soc. 125, 84658475 (2003)
21 Osaki, F., Kanamori, T., Sando, S., Sera, T. and Aoyama, Y., J. Am. Chem. Soc. 126, 65206521 (2004)
22 Freund, L. B. and Lin, Y., J. Mech. Phys. Solids 52, 24552472 (2004)
23 Shenoy, V. B. and Freund, L. B., Proc. Nat. Acad. Sci. 102, 32133218 (2005)
24 Boulbitch, A., Guttenberg, Z. and Sackmann, E., Biophys. J. 81, 27432751 (2001)
25 Guttenberg, Z., Lorz, B., Sackmann, E. and Boulbitch, A., Europhys. Lett. 54, 826832 (2001)
26 Carslaw, H. S. and Jaeger, J. C., Conduction of Heat in Solids 2nd ed. (Oxford University, Oxford, 1959).
27 Dill, K. A. and Bromberg, S., Molecular Driving Force (Garland Science, New York, 2003).
28 Helfrich, W., Z. Naturforsch. C 28, 693703 (1973)
29 Bell, G. I., Science 200, 618627 (1978)
30 van Effenterre, D. and Roux, D., Europhys. Lett. 64, 543549 (2003)
31 Tzlil, S., Deserno, M., Gelbart, W. M. and Ben-Shaul, A., Biophys. J. 86, 20372048 (2004)
32 Briggs, J. A. G., Wilk, T. and Fuller, S. D. J. Gen. Virol. 84, 757768 (2003)
33 Quinn, O., G. Griffiths and Warren, G., J. Cell Biol. 98, 21422147 (1984)
34 Lerner, D. M., Deutsch, J. M. and Oster, G. F., Biophys. J. 65, 7379 (1993)
35 van Effenterre, D. and Roux, D., Europhys. Lett. 64, 543549 (2003)
36 Tzlil, S., Deserno, M., Gelbart, W. M. and Ben-Shaul, A., Biophys. J. 86, 20372048 (2004)

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed