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MgO Nanomaterials Improve Fibroblast Adhesion and Proliferation

Published online by Cambridge University Press:  11 May 2015

Daniel J. Hickey  and
Thomas J. Webster
Daniel J. Hickey
Affiliation:
Department of Chemical Engineering, Northeastern University, Boston, MA 02115, U.S.A.
Thomas J. Webster
Affiliation:
Department of Chemical Engineering, Northeastern University, Boston, MA 02115, U.S.A. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia
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Abstract

Magnesium (Mg) plays an important role in the body mediating cell-extracellular matrix (ECM) interactions, bone apatite structure and density, and nucleic acid chemistries. While Mg has been investigated as a biomaterial for bone applications, it has not been studied for applications within soft tissues. This study investigated, for the first time, the response of fibroblasts to magnesium oxide (MgO) nanoparticles for soft tissue engineering applications. Primary human dermal fibroblasts were cultured both on tissue culture polystyrene in media supplemented with MgO nanoparticles as well as on poly-L-lactic acid (PLLA)-MgO nanoparticle composites. As this study was conducted concurrently with a study aimed at bone tissue engineering, hydroxyapatite (HA) nanomaterials were used for comparison. Results showed for the first time that fibroblasts adhered onto MgO-containing composites roughly three times better than HA-PLLA samples and roughly 4.5 times better than plain PLLA samples. Fibroblasts also proliferated to statistically higher densities when cultured in medium supplemented with MgO nanoparticles compared to un-supplemented medium and medium supplemented with HA nanoparticles. These preliminary results together suggest that MgO nanoparticles should be further investigated as materials to improve the regeneration of soft tissues as well as bone.

Keywords

biomaterialMgnanoscale
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1722: Symposium F – Reverse Engineering of Bioinspired Nanomaterials , 2015 , mrsf14-1722-f05-13
Copyright
Copyright © Materials Research Society 2015 

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