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Matrix Assisted Pulsed Laser Evaporation of Dexamethasone Thin Films

  • Timothy M. Patz (a1), Anand Doraiswamy (a1), Roger J. Narayan (a1), Nicola Menegazzo (a2), Christine Kranz (a2), Boris Mizakoff (a2), Yinghui Zhong (a3), Ravi Bellamkonda (a3), Rohit Modi (a4) and Douglas B. Chrisey (a4)...

Abstract

We have demonstrated deposition of dexamethasone thin films via matrix assisted pulsed laser evaporation (MAPLE). Infrared analysis revealed that dexamethasone thin films deposited by MAPLE and by drop casting had a similar absorbance spectra. AFM imaging of the MAPLE-deposited dexamethasone thin film revealed 2–10 μm punctuate ring-like structures. Deposited dexamethasone was tested for positive bioactivity by treating primary microglia cells with lipopolysacchride and measuring nitric oxide (NO) production. The successful deposition of dexamethasone thin films can be used on neural implants to prevent tissue injury and inflammatory response.

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Matrix Assisted Pulsed Laser Evaporation of Dexamethasone Thin Films

  • Timothy M. Patz (a1), Anand Doraiswamy (a1), Roger J. Narayan (a1), Nicola Menegazzo (a2), Christine Kranz (a2), Boris Mizakoff (a2), Yinghui Zhong (a3), Ravi Bellamkonda (a3), Rohit Modi (a4) and Douglas B. Chrisey (a4)...

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