A laser-based approach, Matrix Assisted Pulsed Laser Direct Write (MAPLE) technique is used to demonstrate two-dimensional direct writing of ceramics such as hydroxyl-apatite and zirconia, for developing inorganic scaffolds. We also demonstrate the patterning of live MG63 osteoblast cells onto various substrates. Our results show successful direct writing of ceramics and live cells concurrently, with a growth profile similar to that of as-deposited cells. After several days of growth, a live/dead assay shows live cells suggesting the biocompatibility of the ceramic and the viability of the process. This investigation demonstrates a novel method of developing heterogeneous tissue scaffolds, such as a cell-ceramic composite by CAD/CAM patterns.