Skip to main content Accessibility help

How the Morphology of Osteocytes Contributes to their Mechanotransduction near Microdamage

  • Elisa Budyn (a1) (a2), Morad Bensidhoum (a3), Patrick Tauc (a4), Eric Deprez (a4) and Herve Petite (a3)...


A dual experimental and numerical top-down approach is applied to investigate the link between osteocyte morphology and mechanical perception of their environment at the progenitor and mature stages. The numerical model is based on explicit tissue morphology discretization to identify bone diffuse damage at the cellular scale. The in vitro experimental model presents a live allograft bone system where a patient progenitor or mature osteocytes were reseeded in fresh human donor cortical bone tissues subjected to mechanical loading. The live systems behaved mechanically as fresh bone and the cells spatially reorganized in vitro as in vivo. The system under mechanical load also showed an adaptation of the calcium membrane transport rate to the expected in vivo mechanical load detected by bone cells at different stages of differentiation.



Hide All
1. Nather, A, David, V, Teng, J W H, Lee, C W, and Pereira, B P. effect of autologous mesenchymal stem cells on biological healing of allografts in critical-sized tibial defects simulated in adult rabbits. Annals Academy of Medicine, 39(8):599606 (2010).
2. Jonvaux, J., Hoc, T. and Budyn, E., Analysis of micro fracture in human Haversian cortical bone under compression, Int. J. Num. Meth. Biomed. Eng., 28(9):974998 (2012).
3. Budyn, E. and Hoc, T., Analysis of micro fracture in human Haversian cortical bone under transverse tension using extended physical imaging., Int. J. Num. Meth. Eng., 82(8):940965 (2010).
4. Wang, Y, McNamara, L M, Schafler, M B, and Weinbaum, S. Strain amplification and integrin based signaling in osteocytes. J. Musculoskelet. Neuronal Interact, 8(4):332334 (2008).
5. Kitase, Y, Van Der Plas, A, Semeins, C M, Ajubi, N E, Frangos, J A, Nijweide, P J, and Burger, E H. Mechanical induction of pge2 in osteocytes blocks glucocorticoid-induced apoptosis through both the beta-catenin and pka pathways. Journal of Bone Mineral Research, 25(12):26572668 (2010).
6. Sun, X, McLamore, E, Kishore, V, Slipchenko, M, Porterfield, D M, and Akkus, O. Mechanical stretch induced calcium efflux from bone matrix stimulates osteoblasts. Bone, 50:581591 (2012).
7. Budyn, E, Tauc, P, Bensidhoum, M, Petite, H, and Deprez, E. Back to life: fresh osteocytes spreading their processes for optimum mechanotransduction near micro damage in dead bone. Medical Engineering Centres Annual Meeting and Bioengineering14, edited by Imperial College London, (MECbioeng14 Imperial College London, England, UK, 2014) ISBN 978-0-9930390-0-3, pp. 63.



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed