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From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph

  • Chih-Kung Lee (a1), Chi-Wan Lin (a2), Shiming Lin (a3), Adam Shih-Yuan Lee (a4), Jiun-Yan Wu (a1), Shu-Sheng Lee (a1), Wen-Hsin Hsiao (a5), Shih-Jui Chen (a1) and An-Bang Wang (a1)...


In this paper, an integrated multifunctional biochip detection system, which we call “OBMorph“, are presented. This unique system integrates several optoelectronic-based biological diagnostic tools such as an ellipsometer, a laser Doppler vibrometer/interferometer, a SPR (surface plasmon resonance) analyzer, an interference microscope, a photon tunneling microscope, an optical coherence tomography unit and a confocal scanning microscope. This OBMorph system, useful as a powerful optical metrology diagnostic tool, can be used at the beginning of sensor chip fabrication, on to signal detecting and monitoring, and to the final biological analysis. The principles and experimental results of this multifunctional biochip detection OBMorph system are presented.

In addition, an innovative SARS (Severe Acute Respiratory Syndrome) virus denaturing chemical compound that was derived using the OBMorph system to study biolinker fabrication in biochips, are discussed. Several testing strategies are presented herein which proves the effectiveness of the new chemical compound, biochip technology in denaturing the SARS virus. Analysis under an atomic force microscope confirms the actual breaking down of the virus treated by the chemical compound. The fundamentals of how the chemical compound denatures the virus and renders it toxicity useless, is based on principles of nanotechnology and bio-mechanics. Results from preliminary studies show that this denaturing principle can be also effective against other deadly viruses and even bacteria. Some design strategies and innovative working mechanisms derived from study of this chemical compound which can denature the SARS-CoV, are also discussed.



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1. Azzam, R. M. A., and Bashara, N. M., Ellipsometry and Polarized Light, North-Holland Publishing Company, New York, New York, USA (1988).
2. Wang, J.S., Lee, Solomon J.H., and Lee, C.K., “Improving the Accuracy of Ellipsometers for Multi-Layer Film Measurements Using Incident Angle Verification and Retrieval,” Liquid Crystal Materials, Devices and Applications, SPIE Proceedings Vol. 3635, pp. 4856 (1999).
3. Acher, O., and Bigan, E., “Improvement of Phase-Modulated Ellipsometry,” Rev. Sci. Instr. Vol. 60, No. 1, pp. 6577 (1989).
4. Born, M., and Wolf, E., Principle of optics 6th ed., Cambridge University Press, Cambridge, (1980).
5. Chandrasekhar, S., Liquid Crystals, Chap. 3, Cambridge University Press, Cambridge, MA, USA (1977).
6. Lee, C. K., Lee, J. H., Shiue, S. C., and Wu, J. Y., “Development of in-situ precision metrological systems: metrological Interface integration of the ellipsometer on a semi-conductor clustertool,” J. Chin. Inst. Auto. Eng., Vol. 12, pp. 3444 (2000).
7. Liedberg, B., Nylander, C., and Lundstrom, I., Surface plasmon resonance for gas detection and biosensing, Sensors and Actuators, pp. 299304 (1983).
8. Furlong, C.E., Woodbury, R.G., Yee, S.S. et al. , “Fundamental system for biosensor characterization: application to surface plasmon resonance (SPR),” SPIE Proc. 2836, pp. 208214 (1996).


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