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Fabrication of Complex Hydrogel Materials by Utilizing Microfluidics and Micromolding

  • Masumi Yamada (a1), Sari Sugaya (a1), Aoi Kobayashi (a1), Ayaki Miyama (a1), Yoji Naganuma (a1), Emi Yamada (a1), Shunta Kakegawa (a1) and Minoru Seki (a1)...

Abstract

Here, we present microfluidic methods to fabricate complex hydrogel structures for 3D tissue or organ-like cell structures in vitro. First, a microfluidic system to continuously synthesize chemically and physically anisotropic Ca–alginate hydrogel microfibers is proposed to enable the guidance of cell proliferation and differentiation. Next, the microfluidic preparation methods for yarn-ball-shape hydrogel particles and extremely-small hydrogel microspheres. Finally, a newly developed micro-molding and bonding method for hydrogel micro-patterned plates is reported.

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[1]. Miyama, A., Yamada, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 825827.
[2]. Sugaya, S., Yamada, M., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 1820.
[3]. Yamada, E., Yamada, M., Iwase, M., Sugaya, S., and Seki, M., Proceedings of MicroTAS2011, edited by Landers, J. et al. ., (Seattle, WA, 2011) pp. 18341836.

Keywords

Fabrication of Complex Hydrogel Materials by Utilizing Microfluidics and Micromolding

  • Masumi Yamada (a1), Sari Sugaya (a1), Aoi Kobayashi (a1), Ayaki Miyama (a1), Yoji Naganuma (a1), Emi Yamada (a1), Shunta Kakegawa (a1) and Minoru Seki (a1)...

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