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Fabrication and antimicrobial effects of silver nanoparticle-poly(N-isopropylacrylamide)-poly(ferrocenylsilane) hydrogel composites

  • Xiaofeng Sui (a1), Xueling Feng (a1), Andrea Di Luca (a2), Clemens A. van Blitterswijk (a2), Lorenzo Moroni (a2), Mark A. Hempenius (a1) and G. Julius Vancso (a1)...


Novel hydrogels composed of thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) and redox-responsive poly(ferrocenylsilane) (PFS) macromolecules were formed by photopolymerization. PFS chains bearing acrylate side groups were copolymerized with NIPAM and N,N’-methylenebisacrylamide in tetrahydrofuran in a predetermined ratio under ultraviolet light-emitting diode (UV-LED) irradiation at a wavelength of 365 nm, in the presence of a photoinitiator. Crosslinking occurred smoothly, providing homogeneous hydrogels. The equilibrium swelling ratio, rheology and morphology of these hybrid PNIPAM-PFS-based hydrogels were investigated. In-situ fabrication of silver nanoparticles inside the hydrogel network via reduction of silver nitrate by the PFS chains led to hydrogel composites. These composites showed strong antimicrobial activity while maintaining a high biocompatibility with cells.



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