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Direct-Write Construction of Tissue-Engineered Scaffolds

  • Anatoly M. Kachurin (a1), Robert L. Stewart (a1), Kenneth H. Church (a1), William L. Warren (a1), John P. Fisher (a2), Antonios G. Mikos (a2), Stine-Katherine Kraeft (a3) and Lan Bo Chen (a3)...

Abstract

A computer-controlled xyz dispensing system called the Biological Architecture Tool (BAT) has been extensively tested in the creation of multilayered and three-dimensional biological objects: tissue scaffolds and plain and patterned cellular-array slides. The BAT dispensing system has proven its versatility and reliability in tissue engineering and biological experiments. The potential employments of modified versions of the xyz dispensers for in vivo minimally invasive surgery and other in vitro aspects of biological and medical research are discussed.

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1. Stock, U. A. and Vacanty, J. P., Ann. Rev. Med. 52, 443 (2001).
2. Behravesh, E. and Mikos, A. G., presented at the MRS Spring Meeting, San Francisco, CA, 2001, in press.
3. Park, A., Wu, B., and Griffith, L. G., J. Biomater. Sci. Polym. Ed. 9, 8 (1998).
4. Behravesh, E., Yasko, A. W., Engel, P. S., and Mikos, A. G., Clin. Orth. Rel. Res. 367S, S118 (1999).
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7. Kraeft, S.-K., Sutherland, R., Gravelin, L., Hu, G. H., Farland, L. H., Richardson, P., Elias, A., and Chen, L. B., Clin. Cancer Res. 6, 434 (2000).

Direct-Write Construction of Tissue-Engineered Scaffolds

  • Anatoly M. Kachurin (a1), Robert L. Stewart (a1), Kenneth H. Church (a1), William L. Warren (a1), John P. Fisher (a2), Antonios G. Mikos (a2), Stine-Katherine Kraeft (a3) and Lan Bo Chen (a3)...

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