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Different Cell Responses on Biologically Inspired Nano-coatings for Orthopedic Applications

Published online by Cambridge University Press:  31 January 2011

Lijie Zhang ,
Usha D. Hemraz ,
Hicham Fenniri  and
Thomas J Webster
Lijie Zhang
Affiliation:
putao1128@gmail.com, Brown University, Division of Engineering, Providence, Rhode Island, United States
Usha D. Hemraz
Affiliation:
uhemraz@ualberta.ca, University of Alberta, National Institute for Nanotechnology and Department of Chemistry, Edmonton, Canada
Hicham Fenniri
Affiliation:
hicham.fenniri@ualberta.ca, University of Alberta, National Institute for Nanotechnology and Department of Chemistry, Edmonton, Canada
Thomas J Webster
Affiliation:
thomas.webster@scholarone.com, Brown, Providence, Rhode Island, United States
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Abstract

Various bone defects, caused by trauma, disease or age-related degeneration, represent a crucial clinical problem all over the world. However, traditional implant materials may cause many complications after surgeries, leading to intense patient pain. Thus, the objective of this in vitro study was to develop a biologically inspired coating on conventional titanium with materials that possess biomimetic nanostructured architectures and favorable surface chemistry. Specifically, self-assembled rosette nanotubes (RNTs) functionalized with various osteogenic peptides and amino acids (such as lysine-arginine-serine-arginine (KRSR), arginine-glycine-aspartic acid (RGD) and lysine (K)) were designed as coatings. Results revealed excellent cytocompatibility properties of these RNTs towards enhancing osteoblast (bone forming cell) and endothelial cell adhesion. In particular, KRSR and RGD functionalized RNTs coated on titanium promoted the greatest osteoblast densities when compared to uncoated titanium. In addition, the KRSR functionalized RNTs selectively improved osteoblast adhesion but not endothelial cell adhesion when coated on titanium. From this study, it can be speculated that the biologically inspired nanotubular structure and osteogenic surface chemistry of RNTs altered the surface properties of titanium to transform it into a more favorable environment for orthopedic applications.

Keywords

nanostructurecoatingbone
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1209: Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology , 2009 , 1209-YY01-05
Copyright
Copyright © Materials Research Society 2010

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References

Referencesa

1 Zhang, L. Sirivisoot, S. Balasundaram, G. and Webster, T. J. in, Micro and Nanoengineering of the Cell Microenvironment: Technologies and A Applications pplications, edited, by Khademhosseini, A. Borenstein, J. Toner, M. and Takayama, S., (Artech House, 2008), p. 431.Google Scholar
2 Chun, A. L. Moralez, J. G. Fenniri, H. and Webster, T. J. Nanotechnology 15, S234 (2004).Google Scholar
3 Zhang, L. Rakotondradany, F. Myles, A. J. Fenniri, H. and Webster, T. J. Bioma Biomaterials terials 30 1309 (2009)Google Scholar
4 Fine, E. Zhang, L. Fenniri, H. and Webster, T. J. Int. J. Nanomed Nanomed. 4, 91 (2009).Google Scholar
5 Zhang, L. Rodriguez, J., Raez, J. Myles, A. J. Fenniri, H. and Webster, T. J. Nanotechnology 20 17510 (2009).Google Scholar
6 Hasenbein, M. E., Andersen, T. T. and Bizios, R., Biomaterials 19 3937 (2002).Google Scholar
7 Nelson, M. Balasundaram, G. and Webster, T. J. Int . J. Nanomed. 1, 339 (2006).Google Scholar
8 Dee, K. C. Andersen, T. T. and Bizios, R. J. Biomed. Mater. Res. 40, 371 (1998).Google Scholar
9 Dalton, B. A. McFarland, C. D., Underwood, P. A. and Steele, J. G. and, J. Cell Sci. 108, 2083 (1995).Google Scholar
10 Fenniri, H., Mathivanan, P., Vidale, K. L. Sherman, D. M. Hallenga, K., Wood, K. V. and Stowell, J. G., J. Am. Chem. Soc. 123, 3854 (2001).Google Scholar
11 Webster, T. J., in Advances in Chemical Engineering Engineering edited by Ying, J. Y. (Academic Press, 2001), p.125.Google Scholar
12 Balasundaram, G. and Webster, T. J. J. Biomed. Mater. Res. 80A 602 (2007).Google Scholar