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Development of a Simple and Highly Sensitive Microbalance for Measurements of Total Particle Yields in Matrix Assisted Laser Desorption

  • T. Huth-fehre (a1), A.P. Quist (a1), S-O. Linder (a1) and B.U.R. Sundqvist (a1)

Abstract

In order to open a new window for getting insight into the process of matrix assisted laser desorption ionization (MALDI) of biopolymers, a highly sensitive quartz crystal microbalance (QCM) was developed to measure desorption yields of neutral particles. For the matrix substances commonly used the mass resolution of 0.95 ng obtained with the balance corresponds to a detection limit of ∼1012 particles.

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Development of a Simple and Highly Sensitive Microbalance for Measurements of Total Particle Yields in Matrix Assisted Laser Desorption

  • T. Huth-fehre (a1), A.P. Quist (a1), S-O. Linder (a1) and B.U.R. Sundqvist (a1)

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