Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-19T06:33:04.551Z Has data issue: false hasContentIssue false
  • English
  • Français

Design of Bioerodible Devices with Optimal Release Characteristics

Published online by Cambridge University Press:  15 February 2011

Kyriacos Zygourakis
Kyriacos Zygourakis*
Affiliation:
Dept. of Chemical Engineering and Institute of Biosciences and Bioengineering, Rice University, Houston, TX.
Get access

Abstract

The development of a computational tool to design bioerodible devices with optimal release characteristics is presented. This computational tool uses cellular automata and discrete iterations to model and simulate the release of bioactive agents (drugs) from bioerodible matrices. The simulations can accurately model surface erosion processes in multicomponent systems of arbitrary geometry and with different dissolution rates for each component. Simulation results are analyzed to show how the overall release rates are affected by the intrinsic dissolution rates, drug loading and the dispersion of the drug in the bioerodible matrix. Heterogeneities in the structure of the bioerodible matrix that can lead to local variations of erosion rates are also considered. A strongly nonlinear dependence of release rates on drug loading and dispersion is obtained and the effects of matrix heterogeneities are elucidated. Finally, guidelines are presented for screening of alternatives to minimize the development effort and experimentation required for designing devices with desired release characteristics.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 79
Copyright
Copyright © Materials Research Society 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Brem, H., Mahaley, M.S., Vick, N.A., Black, K.L., Schold, S.C., Burger, P.C., Friedman, A.H., Ciric, I.S., Eller, T.W., Cozzens, J.W. and Kenally, J.N., J. Neurosurg. 74, 441 (1991).Google Scholar
2. Leenslag, J.W., Pennings, A.J., Ruud, R. M., Rozema, F. R. and Boering, G., Biomaterials, 8, 70 (1987).Google Scholar
3. Li, C., and Kohn, J., Macromolecules, 22, 2029 (1989).Google Scholar
4. Langer, R., Chem. Eng. Commun. 6, 1 (1980).Google Scholar
5. Rosen, H.B., Kohn, J., Leong, K. and Langer, R., in Controlled Release Systems: Fabrication Technology, edited by Hsieh, D.S.T. (CRC Press, Boca Raton, FL, 1988) p. 83.Google Scholar
6. Zygourakis, K., Polymer Prepr. (Amer. Chem. Soc., Div. Polym. Chem.) 30, 456 (1989).Google Scholar
7. Zygourakis, K., Chem. Eng. Sci. 45, 2359 (1990).Google Scholar
8. Göpferich, A. and Langer, R., Macromolecules, 26, 4105 (1993).Google Scholar
9. Cooney, D.O., AIChE J. 18, 446 (1972).Google Scholar