Skip to main content Accessibility help
×
Home

Control and Characterization of Protein Adsorption on Ceramic Surfaces

  • M. J. Read (a1), S. L. Burkett (a1) (a2) and A. M. Mayes (a1)

Abstract

Protein adsorption to ceramic surfaces is an important early step in the function of implants. The types and amounts of adsorbed protein and the resulting conformational changes could mediate subsequent cell adhesion and inorganic deposition. Microporous silicoalumino-phosphates, which allow variations in surface composition within the same crystal structure, have been used as model surfaces. Effects of surface composition on adsorption isotherms, elutability, and biological activity of the adsorbed protein layer have been studied using lysozyme, a model protein. Control over protein adsorption mechanisms using well-characterized surface properties could be used to predict the biological properties of surfaces, and engineer coatings for a desired response.

Copyright

References

Hide All
[1] Gupta, R. K. and Siber, G. R., Vaccine 13, 12631275 (1995).
[2] Leitao, E., Barbosa, M. A., and Groot, K. de, J. Mater. Sci.: Mater. Med. 6, 849 (1995).
[3] Hench, L. L., J. Am. Ceram. Soc. 74, 14871510 (1991).
[4] Rupp, F., Geis-Gerstorfer, J., and Geckeler, K. E., Adv. Mater. 8, 254 (1996).
[5] Kobayashi, M., Nakamura, T., Tamura, J., lida, H., Fujita, H., Kokubo, T., and Kikutani, T., J. Biomed. Mater. Res. 37, 68 (1997).
[6] Hasha, D., Saldarriaga, L. S. de, Saldarriaga, C., Hathaway, P. E., Cox, D. F., and Davis, M. E., J. Am. Chem. Soc. 110, 21272135 (1988).
[7] Arai, T. and Norde, W., Colloid Surf. 51, 1 (1990).
[8] Bower, C. K., Xu, Q., and McGuire, J., Biotechnol. Bioengng. 58, 659 (1998).
[9] Nagadome, H., Kawano, K., and Terada, Y., FEBS Letters 317, 128130 (1993).
[10] Furness, E. L., Ross, A., Davis, T. P., and King, G. C., Biomaterials 19, 1361 (1998).
[11] Norde, W. and Haynes, C. A., in Proteins at Interfaces II: Fundamentals and Applications, edited by Horbett, T. A. and Brash, J. L. (American Chemical Society, Washington DC, 1995), pp. 2639.
[12] Sarkar, D. and Chattoraj, D. K., Colloid, J. Interface Sci. 178, 606613 (1996).
[13] Wahlgren, M. and Arnebrant, T., Langmuir 13, 8 (1997).
[14] EIwing, H., Welin, S., Askendal, A., Nilsson, U., and Lundstrom, I., J. Colloid Interface Sci. 119, 203 (1987).
[15] Norde, W. and Favier, J. P., Colloid Surf. 64, 87 (1992).
[16] Rapoza, R. J. and Horbett, T. A., J. Colloid Interface Sci. 136, 480 (1990).

Control and Characterization of Protein Adsorption on Ceramic Surfaces

  • M. J. Read (a1), S. L. Burkett (a1) (a2) and A. M. Mayes (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed