Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-24T09:05:25.413Z Has data issue: false hasContentIssue false
  • English
  • Français

Conduction Properties in Peripheral Nerve Fibers Regenerated by Biodegradable Polymer Matrix

Published online by Cambridge University Press:  26 February 2011

Albert S. Chang ,
Ioannis V. Yannas ,
Christian Krarup ,
Rajesh Sethi ,
Thor V. Norregaard  and
Nicholas T. Zervas
Albert S. Chang
Affiliation:
Fibers and Polymers Lab, Massachusetts Institute of Technology, Cambridge MA 02139
Ioannis V. Yannas
Affiliation:
Fibers and Polymers Lab, Massachusetts Institute of Technology, Cambridge MA 02139
Christian Krarup
Affiliation:
Division of Neurology, Brigham and Women's Hospital, Boston MA 02115
Rajesh Sethi
Affiliation:
Division of Neurology, Brigham and Women's Hospital, Boston MA 02115
Thor V. Norregaard
Affiliation:
Department of Surgery, University of Illinois, Chicago, IL 60612
Nicholas T. Zervas
Affiliation:
Division of Neurosurgery, Mass. General Hospital, Boston MA 02114
Get access

Abstract

The rat sciatic nerve was transected mid-thigh and grafted with a silicone tube, the central 10 mm of which was filled with a collagen-glycosaminoglycan (CG) matrix. The rats were grafted contralaterally with empty silicone tubes as controls. The earliest compound muscle action potentials (CMAP's) at the plantar muscles were recorded around 11 weeks. After 30 weeks, the distal motor latencies recovered to about 50% higher than normal, the conduction velocity to about 50% normal, and the amplitudes of the CMAP's to about 50% normal. Of 7 rats in this study, all 7 nerves grafted with the CG matrix exhibited recovery, while only 1 grafted with the empty tube exhibited recovery. The CG matrix therefore appears to promote functional nerve regeneration across extended distances.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 3
Copyright
Copyright © Materials Research Society 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Achparaki-Alvanou, A., Manthos, A., Kontopoulos, V., Kerameos-Foroglou, Ch. and Foroglou, G., Acta Neurochir. (Wien) 85, 172 (1987).Google Scholar
2. Colin, W. and Donoff, R.B., J. Dent. Res. 63(7), 987 (1984).Google Scholar
3. Kline, D.G. and Hudson, A.R., Surg. Neurol. 24, 371 (1985).CrossRefGoogle Scholar
4. Lundborg, G., Acta. Orthop. Scand. 58, 145 (1987).Google Scholar
5. Molander, H., Engkvist, O., Hägglund, J., Olsson, Y. and Torebjörk, E., Biomaterials 4, 276 (1983).CrossRefGoogle Scholar
6. Muller, H. and Grfibel, G., Arch. Orthop. Trauma. Surg. 102, 51 (1983).Google Scholar
7. Seddon, H., Surgical Disorders of the Peripheral Nerves, 2nd ed. (Churchill Livingstone, Edinburgh London and New York, 1975).Google Scholar
8. Yannas, I.V., Burke, J.F., Orgill, D.P. and Skrabut, E.M., Science 215, 174 (1982).Google Scholar
9. Yannas, I.V., Orgill, D.P., Silver, J., Norregaard, T., Zervas, N.T. and Schoene, W.C., Trans. Soc. Biomaterials 9, 175 (1986).Google Scholar
10. Yannas, I.V., Orgill, D.P., Silver, J., Norregaard, T.V., Zervas, N.T. and Schoene, W.C., Advances in Biomedical Polymers, Gebelein, Charles G., Ed. (Plenum Publishing Corporation, 1987).Google Scholar