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Cholesterol Biosensor Based on Nanodiamond-Polypyrrole Conducting Nanocomposite Membrane

  • Pedro Villalba (a1) (a2) (a3), Punya Basnayaka (a2) (a4), Mikhail Ladanov (a2), Beverly Liriano (a4), Manoj Ram (a2) (a4), Subhra Mohapatra (a5) and Ashok Kumar (a2) (a4)...

Abstract

In this work we present the synthesis, characterization and application of the nanodiamond- polypyrrole nanocomposite films as electrochemical active electrode for sensing cholesterol. Cholesterol oxidase and esterase have been covalently attached to the surface of the films. Results showed that the inclusion of nanodiamond to the polymeric matrix increment the surface area and provide carboxylic groups capable to perform reaction with the amide groups present in the enzymes. Further, the sensitivity of the electrode to the cholesterol content have been examined.

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[1] Tak-Shing Ching, C., “Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring,” International Journal of Nanomedicine, p. 343, May 2010.10.2147/IJN.S10247
[2] Villalba, P., Ram, M. K., Gomez, H., Kumar, A., Bhethanabotla, V., and Kumar, A., “GOX-functionalized nanodiamond films for electrochemical biosensor,” Materials Science and Engineering: C, vol. 31, no. 5, pp. 11151120, Jul. 2011.10.1016/j.msec.2011.04.008
[3] Tsai, Y.-C., Li, S.-C., and Liao, S.-W., “Electrodeposition of polypyrrole–multiwalled carbon nanotube–glucose oxidase nanobiocomposite film for the detection of glucose,” Biosensors and Bioelectronics, vol. 22, no. 4, pp. 495500, Oct. 2006.10.1016/j.bios.2006.06.009
[4] Xu, Hui, Li, Guang, Fu, Min, Wang, You, and Liu, Jun, “Study of carbon nanotube modified biosensors for monitoring uric acid and total cholesterol in blood,” in Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference, 2006, pp. 255258.
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Keywords

Cholesterol Biosensor Based on Nanodiamond-Polypyrrole Conducting Nanocomposite Membrane

  • Pedro Villalba (a1) (a2) (a3), Punya Basnayaka (a2) (a4), Mikhail Ladanov (a2), Beverly Liriano (a4), Manoj Ram (a2) (a4), Subhra Mohapatra (a5) and Ashok Kumar (a2) (a4)...

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