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Bioresorbable Microspheres as Injectable Cell Carrier: FRom Preparation to in Vitro Evaluation

Published online by Cambridge University Press:  15 February 2011

Y. Senuma ,
S. Franceschin ,
J. G. Hilborn ,
P. Tissiéres  and
P. Frey
Y. Senuma
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
S. Franceschin
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
J. G. Hilborn
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
P. Tissiéres
Affiliation:
Pediatric Surgery, Centre Hospitalier du Canton de Vaud, Switzerland
P. Frey
Affiliation:
Pediatric Surgery, Centre Hospitalier du Canton de Vaud, Switzerland
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Abstract

A new approach to the vesico-ureteral reflux could be a local regeneration of the defective vesicoureteral junction by transplanting living cells to the target site. The aim of this work is to provide a long-term effective treatment by producing bioresorbable microspheres which can act as support matrix for those cells, with the goal of an in vivo transfer of the in vitro cultured cells with a minimal surgical procedure. After microsphere degradation, the cells should be integrated into the muscular structure of the junction. Most innovative is that these are cultured muscle and urothelial cells from the bladder of the same patient.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 183
Copyright
Copyright © Materials Research Society 1999

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