Skip to main content Accessibility help
×
Home

Actinide Complexation with Biomimetic Phosphorylated Molecules

  • Samir Safi (a1) (a2), Marie Christine Charbonnel (a2), Gaelle Creff (a1) (a3), Aurélie Jeanson (a1), Sarah Mostapha (a2), Jerome Roques (a1), Eric Simoni (a1), Pier Solari (a4), Claude Vidaud (a3) and Christophe Den Auwer (a2) (a5)...

Abstract

Most data available on the interaction of actinides with biological systems are based on physiological or biokinetic measurements, with scarce information on the structure of the actinide coordination site. This proceeding article describes an approach for structural elucidation of actinide biological complexes. Indeed most of c.a. actinide circulation pathways are unknown, as they accumulate mostly in bones, kidney and liver. In case of accidental release of radionuclide in the environment, internal contamination under either acute or chronic conditions has the potential to induce both radiological and chemical toxicity through significant interaction with the metabolome or proteome followed by possible functional modifications. For instance, the metalloproteins present primary, secondary and tertiary structures, and also different post-translational modifications, all playing a crucial role in interacting with their partners, which can be altered by actinide bonding. When tightly bound, metal ions are critical to the function, structure, and stability of the proteins, by disabling specific interactions through significant local or global conformational modifications. In order to overcome the intricacy of actinide chemistry combined with that of metalloproteins, a simplified study toward better understanding the interaction of actinides and biological systems using simple biomolecules such as amino acids has therefore been considered. Focus is made on the cation coordination site itself, given that conformational effects are not taken into account in this approach. In a first step, we have selected simple phosphorylated building blocks that may be considered as chemical representatives of some ubiquitous target metalloproteins or some important phosphorylated peptides or proteins.

Copyright

References

Hide All
1. Durbin, P.W., Actinides in animals and man, the chemistry of actinide and transactinide elements Vol. 5 pp 3339.
2. Breitenstein, B.D. and Palmer, H.E., Radiat. Prot. Dosim., 26 (1989) 317.
3. Hill, A.R. Jr., Orgel, L.E., Bioconjugate Chem. 2 (1991) 431
4. Dedieu, A., Bérenguer, F., Basset, C., Prat, O., Quéméneur, E., Pible, O., Vidaud, C., Journal of Chromatography A, 1216 (2009) 5365.
5. Terra, O., Dacheux, N., Clavier, N., Podor, R., Audubert, F., J. Am. Cer. Soc. 91 (2008) 3673.
6. Gunther, A., Geipel, G., Bernhard, G., Radiochim. Acta 94 (2006) 845.
7. Szabo, I. Furo, I. Csoregh, J. Am. Chem. Soc. 127 (2005) 15236
8. Agarwal, R.P., Feldman, I., J.Am. Chem. Soc. 90 (1968) 6635.
9. Andreev, G., Budantseva, N., Sokolova, M., Tananaev, I., Myasoedov, B., Inorg.Chem. 48 (2009) 2343.
10. Frisch, M. J. and al. gaussian 03, Revision C.02; Gaussian, Inc.: Wallingford, (2004).
11. Becke, A. D. J., Chem. Phys. 98 (1993) 5648.
12. Kuchle, W., Dolg, M., Stoll, H., Preuss, H. J Chem Phys 100 (1994) 7535.
13. Barone, V., Cossi, M., J Phys Chem A 102 (1998) 199.
14. Sitaud, B., Solari, P. L., Schlutig, S., Llorens, I., Hermange, H., J.Nucl. Materials, (2012) in press.
15. Solari, P. L., Schlutig, S., Hermange, H., Sitaud, B., Proceedings of the 14th International Conference On X-Ray Absorption Fine Structure (Xafs14), J Phys Conf, 190 (2009) 012042.
16. Ravel, B. and M. J. Newville Synch. Rad. 12 (2005) 537.
17. Rehr, J. J., Albers, R. C., Rev. Mod. Phys., 2000, 72, 621.
18. Cimas, A., Maitre, P., Ohanessian, G., Gaigeot, M-P., J. Chem. Theory Comput. 5 (2009), 2388.
19. Brandel, V., Dacheux, N., Genet, M., Podor R, R.., J. Solid State Chem., 159 (2001), 139.
20. Kelly, S. D., Kemner, K. M., Fein, J. B., Fowle, D. A., Boyanov, M. I., Bunker, B. A. and Yee, N., Geochim. Cosmochim. Acta 66 (2002) 3855.
21. Glowiak, T., Huskowska, E., Legendziewicz, J., Polyhedron 10 (1991), 175.
22. Tajmir-riahi, H.A., Theophanides, T., Inorg. Chim.Acta, 80 (1983) 183
23. Tajmir-Riahi, H.A., Biopolymers 31 (1991) 1065.

Keywords

Related content

Powered by UNSILO

Actinide Complexation with Biomimetic Phosphorylated Molecules

  • Samir Safi (a1) (a2), Marie Christine Charbonnel (a2), Gaelle Creff (a1) (a3), Aurélie Jeanson (a1), Sarah Mostapha (a2), Jerome Roques (a1), Eric Simoni (a1), Pier Solari (a4), Claude Vidaud (a3) and Christophe Den Auwer (a2) (a5)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.