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Oligonuleotide Delivery with Dendritic Poly(L-lysine) for Treatments of the Liver Disorders

Published online by Cambridge University Press:  31 January 2011

Kazuto Watanabe
Affiliation:
kazuto@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Mriko Harada-Shiba
Affiliation:
mshiba@ri.ncvc.go.jp, National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Akira Suzuki
Affiliation:
asuzuki@ri.ncvc.go.jp, National Cardiovascular Center Research Institute, Department of Bioscience, Osaka, Japan
Yuriko Higuchi
Affiliation:
higuchi@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Shigeru Kawakami
Affiliation:
kawakami@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Mitsuru Hashida
Affiliation:
hashidam@pharm.kyoto-u.ac.jp, Kyoto University, Department of Drug Delivery Research, Kyoto, Japan
Risa Gokuden
Affiliation:
risa.g@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Ryohsuke Kurihara
Affiliation:
r-kurihara@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yusuke Sugao
Affiliation:
s-you@mail.cstm.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takeshi Mori
Affiliation:
mori.takeshi.880@m.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Yoshiki Katayama
Affiliation:
ykatatcm@mbox.nc.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
Takuro Niidome
Affiliation:
niidome.takuro.655@m.kyushu-u.ac.jpniidome-tcm@mbox.nc.kyushu-u.ac.jp, Kyushu University, Department of Applied Chemistry, Fukuoka, Japan
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Abstract

A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).

Type
Research Article
Copyright
Copyright © Materials Research Society 2010

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