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Mechanism of Apatite Formation on Bioactive Titanium Metal

Published online by Cambridge University Press:  10 February 2011

T. Kokubo ,
H.-M. Kim ,
H. Takadama ,
M. Uchida ,
S. Nishiguchi  and
T. Nakamura
T. Kokubo
Affiliation:
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606–8501, Japan, kokubo@sung7.kuic.kyoto-u.ac.jp.
H.-M. Kim
Affiliation:
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606–8501, Japan, kokubo@sung7.kuic.kyoto-u.ac.jp.
H. Takadama
Affiliation:
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606–8501, Japan, kokubo@sung7.kuic.kyoto-u.ac.jp.
M. Uchida
Affiliation:
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606–8501, Japan, kokubo@sung7.kuic.kyoto-u.ac.jp.
S. Nishiguchi
Affiliation:
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606–8507, Japan
T. Nakamura
Affiliation:
Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606–8507, Japan
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Abstract

The present authors previously showed that titanium metal, which was exposed to 5.OMNaOH solution at 60°C for 24 h and heat-treated at 600°C for 1 h, spontaneously forms a bonelike apatite layer on its surface in the living body, and tightly bonds to the bone through the apatite layer. In the present study, mechanism of the apatite formation on the bioactive titanium metal was investigated in an acellular simulated body fluid (SBF). A thin sodium titanate layer was formed on the surface of the titanium metal by the NaOH and heat treatments. The sodium titanate layer released Na+ ions via exchange with H3O+ ions in SBF, to form a lot of Ti-OH groups on its surface. The Ti-OH groups first combined with Ca2+ ions in SBF, and then later with PO43- ions to form the apatite. Titania and Na2O-TiO2 gels prepared by a sol-gel method as model substances of the sodium titanate layer on the surface of the titanium metal showed that Ti-OH groups of anatase structure are effective for the apatite nucleation, whereas those of amorphous structure and Na2Ti5O11 crystal are not effective.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 129
Copyright
Copyright © Materials Research Society 2000

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