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From an Integrated Biochip Detection System to a Defensive Weapon Against the SARS-CoV Virus: OBMorph

Published online by Cambridge University Press:  15 March 2011

Chih-Kung Lee
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan
Chi-Wan Lin
Affiliation:
Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
Shiming Lin
Affiliation:
Center for Optoelectronic Biomedicine, National Taiwan University, Taipei, Taiwan
Adam Shih-Yuan Lee
Affiliation:
Department of Chemistry, Tamkang University, Tamshui, Taiwan
Jiun-Yan Wu
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan
Shu-Sheng Lee
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan
Wen-Hsin Hsiao
Affiliation:
AdvanceWave Technologies Inc., Taipei, Taiwan
Shih-Jui Chen
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan
An-Bang Wang
Affiliation:
Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan
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Abstract

In this paper, an integrated multifunctional biochip detection system, which we call “OBMorph“, are presented. This unique system integrates several optoelectronic-based biological diagnostic tools such as an ellipsometer, a laser Doppler vibrometer/interferometer, a SPR (surface plasmon resonance) analyzer, an interference microscope, a photon tunneling microscope, an optical coherence tomography unit and a confocal scanning microscope. This OBMorph system, useful as a powerful optical metrology diagnostic tool, can be used at the beginning of sensor chip fabrication, on to signal detecting and monitoring, and to the final biological analysis. The principles and experimental results of this multifunctional biochip detection OBMorph system are presented.

In addition, an innovative SARS (Severe Acute Respiratory Syndrome) virus denaturing chemical compound that was derived using the OBMorph system to study biolinker fabrication in biochips, are discussed. Several testing strategies are presented herein which proves the effectiveness of the new chemical compound, biochip technology in denaturing the SARS virus. Analysis under an atomic force microscope confirms the actual breaking down of the virus treated by the chemical compound. The fundamentals of how the chemical compound denatures the virus and renders it toxicity useless, is based on principles of nanotechnology and bio-mechanics. Results from preliminary studies show that this denaturing principle can be also effective against other deadly viruses and even bacteria. Some design strategies and innovative working mechanisms derived from study of this chemical compound which can denature the SARS-CoV, are also discussed.

Type
Research Article
Copyright
Copyright © Materials Research Society 2004

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References

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