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Cell colonization of scaffolds for tissue engineering enhanced by means of plasma processes

Published online by Cambridge University Press:  21 May 2012

P. Favia
Affiliation:
Department of Chemistry, University of Bari “A. Moro”, Italy CNR-Institute of Inorganic Methodologies and Plasmas, IMIP-CNR, Bari, Italy Plasma Solution Srl, Spin Off dell’Università di Bari “A. Moro”, Italy
E. Sardella
Affiliation:
CNR-Institute of Inorganic Methodologies and Plasmas, IMIP-CNR, Bari, Italy
R.A.H. Salama
Affiliation:
Biomaterials Department, Faculty of Oral and Dental Medicine, Cairo University, Egypt
V. R. Giampietro
Affiliation:
Department of Chemistry, University of Bari “A. Moro”, Italy
F. Intranuovo
Affiliation:
Department of Chemistry, University of Bari “A. Moro”, Italy
M. Nardulli
Affiliation:
Department of Chemistry, University of Bari “A. Moro”, Italy
R. Gristina
Affiliation:
CNR-Institute of Inorganic Methodologies and Plasmas, IMIP-CNR, Bari, Italy
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Abstract

Synthetic biodegradable polymers are commonly used as scaffolds for tissue engineering despite their poor cell adhesion compared to natural polymers. One of the problems in using biodegradable scaffolds is that a higher cell colonization at the scaffold periphery and inadequate colonization at its center is generally noted. Such aspects could seriously compromise the in vivo regeneration of a damaged tissue and, in turn, the success of the implant. Plasma processes have been lately proven as promising scaffold modification techniques. The current work aims at enhancing cell colonization in the core of polymer scaffolds via plasma deposition of coatings with different chemical characteristics. The versatility and ability of plasma processes to modify only the outermost layer of a material can render them competitive with respect to wet chemistry approaches in the field of biomedical materials. In this paper some of the results obtained by plasma processing of 3D interconnected porous polymer scaffolds for Tissue Engineering will be shown. In particular, it will be shown how it is possible to enhance cell adhesion, growth and colonization in porous Polycaprolactone (PCL) scaffolds where gradient of surface compositions are induced from the external (e.g., hydrophobic, slightly cell-repulsive) to the internal (e.g., hydrophilic, cell-adhesive) side of the scaffolds. 3D scaffolds were modified with several RF (13.56 MHz) deposition and treatment plasma processes. Materials were characterized by means of XPS, and FT-IR techniques. Cell-growth experiments were run with cell-lines to check the efficiency of several treatments to enhance/accelerate cell in-growth inside scaffolds.

Type
Research Article
Copyright
Copyright © Materials Research Society 2012

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References

1. Liu, X., Ma, P. X., Annals of Biomedical Engineering, 2004. 32(3), 477 10.1023/B:ABME.0000017544.36001.8eCrossRefGoogle Scholar
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4. Intranuovo, F, Howard, D., White, L. J., Johal, R. K., Ghaemmaghami, A. M., Favia, P., Howdle, S. M., Shakesheff, K. M., Alexander, M. R., Acta Biomater. 2011. 7(9), 3336 10.1016/j.actbio.2011.05.020CrossRefGoogle Scholar
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