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Aspects of Polymer Erosion

Published online by Cambridge University Press:  21 February 2011

Achim Göpferich
Affiliation:
University of Erlangen-Ntirnberg, Department of Pharmaceutical Technology, Cauerstrasse 4, D-91058 Erlangen, Germany Massachusetts Institute of Technology, Department of Chemical Engineering, Building E25–342, Cambridge, MA, 02139, U.S.A.
Lisa Shieh
Affiliation:
Massachusetts Institute of Technology, Department of Chemical Engineering, Building E25–342, Cambridge, MA, 02139, U.S.A.
Robert Langer
Affiliation:
Massachusetts Institute of Technology, Department of Chemical Engineering, Building E25–342, Cambridge, MA, 02139, U.S.A.
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Extract

The importance of non-enzymatic chemical erosion for the release of drugs from degradable polymers is discussed. In order to have purely erosion controlled systems, polymer erosion has to be faster than polymer swelling or drug diffusivity inside degradable polymers. Therefore, fast hydrolyzing polymers are especially suited for the manufacture of erosion controlled drug delivery systems. Poly(anhydrides) are one such polymer class and are presented in more detail. It is shown that it is possible to predict drug release from such systems using discrete Monte Carlo Models. Such models are useful for the design of new implant type drug delivery systems.

Type
Research Article
Copyright
Copyright © Materials Research Society 1995

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References

[1] Langer, R. and Peppas, N., J. Macromol. Sci.-Rev. Macromol. Chem. Phys. C23, 61126, (1983).CrossRefGoogle Scholar
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[4] Göpferich, A. and Langer, R., J. Polymer Science: Part A: Polymer Chemistry, 31, 24452458 (1993).CrossRefGoogle Scholar
[5] Shieh, L., Tamada, J., Chen, I., Pang, J., Domb, A., Langer, R., J. Biomed. Mater. Res., 28, 1465–75, 1994.CrossRefGoogle Scholar
[6] Göpferich, A. and Langer, R., Macromolecules, 12,41054112 (1993).CrossRefGoogle Scholar
[7] Göpferich, A. and Langer, R., AIChE Journal, in press (1995).Google Scholar
[8] Pitt, C.G., in Biodegradable Polymers and Plastics, edited by Vert., M. Feijen, J., Albertson, A., Scott, G. and Chiellini, E. (Redwood Press Ltd., England, 1992), pp. 720.Google Scholar
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