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Advanced Functional Graphite-Coated Magnetic Nanoparticles as RF Thermal Ablation Agents for Cancer Therapies

Published online by Cambridge University Press:  01 February 2011


Yang Xu
Affiliation:
yxxu@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Meena Waleed Mahmood
Affiliation:
mwmahmood@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Zhongrui Li
Affiliation:
zxli3@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Enkeleda Dervishi
Affiliation:
exdervishi@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Steve Trigwell
Affiliation:
steven.trigwell-1@nasa.gov, NASA, Electrostatics & Surface Physics Laboratory, ASRC Aerospace, Kennedy Space Center, Florida, United States
Vladimir P. Zharov
Affiliation:
zharovvladimirp@uams.edu, University of Arkansas for Medical Sciences, Phillips Classic Laser Laboratories, Little Rock, Arkansas, United States
Nawab Ali
Affiliation:
nali@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Viney Saini
Affiliation:
vxsaini@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States
Alexandru R. Biris
Affiliation:
abiris@yahoo.com, National Institute for Research & Development of Iostopic & Molecular Technologies, Cluj Napoca, Romania
Dan Lupu
Affiliation:
danlupu@gmail.com, National Institute for Research & Development of Iostopic & Molecular Technologies, Cluj Napoca, Romania
Alexandru S. Biris
Affiliation:
asbiris@ualr.edu, University of Arkansas at Little Rock, Nanotechnology Center & Applied Science Department, Little Rock, Arkansas, United States

Abstract

Graphitic shells coated ferromagnetic cobalt nanoparticles (C-Co-NPs) with diameters of around 7-9 nm cubic crystalline structures were synthesized by catalytic chemical vapor deposition (CCVD). X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis indicated that the Co-NPs inside the carbon shells were preserved in the metallic state. Confocal microscope images revealed effective penetrations of C-Co-NPs through plasmatic membranes into the nucleus of the cultured HeLa cancerous cells. Low RF radiation of 350 kHz triggered the cell death, process that was found to be dependent on the NPs concentration and application time. Compared to carbon nanostructures such as single wall carbon nanotubes, super paramagnetic cobalt nanoparticles demonstrated higher specificity for RF absorption and heating. This work indicates a great potential of a new technology for tumor thermal ablation.


Type
Research Article
Copyright
Copyright © Materials Research Society 2009

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References

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