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The effects of fluid composition and shear conditions on bacterial adhesion to an antifouling peptide-coated surface

  • Patrícia Alves (a1), Sivan Nir (a2), Meital Reches (a2) and Filipe Mergulhão (a1)

Abstract

Biofilms can damage implants and are difficult to treat. Here, we assessed the performance of a tripeptide that self-assembles into an antifouling coating over a broad range of shear conditions that are relevant to biomedical applications. Adhesion assays were performed using a parallel plate flow chamber. The results show that the coating can reduce Escherichia coli adhesion up to 70% when compared with glass. At a shear rate of 15/s, typical for urinary catheters, the coating reduced the adhesion by more than 50%. These findings suggest critical features that should be considered when developing surfaces for biomedical purposes.

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Corresponding author

Address all correspondence to Meital Reches and Filipe Mergulhão at E-mail: meital.reches@mail.huji.ac.il and filipem@fe.up.pt

References

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Supplementary materials

Alves et al. supplementary material
Tables S1 and Figures S1-S2

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The effects of fluid composition and shear conditions on bacterial adhesion to an antifouling peptide-coated surface

  • Patrícia Alves (a1), Sivan Nir (a2), Meital Reches (a2) and Filipe Mergulhão (a1)

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