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Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy

Published online by Cambridge University Press:  18 April 2018

Ncediwe Tsolekile
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Vuyelwa Ncapayi
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Sundararajan Parani
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
El Hadji Mamour Sakho
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Mangaka C. Matoetoe
Affiliation:
Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Sandile P. Songca
Affiliation:
Department of Chemistry, University of Zululand, PB X1001, Kwadlangezwa 3886, South Africa
Oluwatobi S. Oluwafemi
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Corresponding
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Abstract

Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

Type
Research Letters
Copyright
Copyright © Materials Research Society 2018 

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References

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Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy
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