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MRS Communications MRS Communications

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Synthesis of fluorescent CuInS2/ZnS quantum dots—porphyrin conjugates for photodynamic therapy

Published online by Cambridge University Press:  18 April 2018

Ncediwe Tsolekile ,
Vuyelwa Ncapayi ,
Sundararajan Parani ,
El Hadji Mamour Sakho ,
Mangaka C. Matoetoe ,
Sandile P. Songca  and
Oluwatobi S. Oluwafemi
Ncediwe Tsolekile
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Vuyelwa Ncapayi
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Sundararajan Parani
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
El Hadji Mamour Sakho
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Mangaka C. Matoetoe
Affiliation:
Department of Chemistry, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 2000, South Africa
Sandile P. Songca
Affiliation:
Department of Chemistry, University of Zululand, PB X1001, Kwadlangezwa 3886, South Africa
Oluwatobi S. Oluwafemi
Affiliation:
Department of Applied Chemistry, University of Johannesburg, P. O. Box 17011, Doornfontein 2028, Johannesburg, South Africa Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, South Africa
Corresponding
E-mail address:
ooluwatobi@uj.ac.za
Oluwafemi.oluwatobi@gmail.com
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Abstract

Porphyrins are photosensitisers used in photodynamic therapy (PDT) due to their tumor localization and in situ singlet oxygen generation. However, their limited absorption, insolubility, and aggregation in an aqueous medium limited their effective application in PDT. To overcome these limitations, we herein, report a large-scale aqueous synthesis of CuInS2/ZnS ternary quantum dots, and its conjugation to 5, 10, 15, 20-meso(4-hydroxyphenyl) porphyrin. The singlet oxygen generation of this highly aqueous soluble novel conjugate shows its potential for PDT applications.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 2 , June 2018 , pp. 398 - 403
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Copyright
Copyright © Materials Research Society 2018 

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References

1.Allison, R.R., and Moghissi, K.: Photodynamic therapy (PDT): PDT mechanisms. Clin. Endosc. 46, 24–29 (2013).CrossRefGoogle ScholarPubMed
2.Subramanian, A.P., Jaganathan, S.K., Manikandan, A., Pandiaraj, K.N., Gomathi, N., and Supriyanto, E.: Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy. RSC Adv. 6, 48294–48314 (2016).CrossRefGoogle Scholar
3.Debele, T.A., Peng, S., and Tsai, H.C.: Drug carrier for photodynamic cancer therapy. Int. J. Mol. Sci. 16, 22094–22136 (2015).CrossRefGoogle ScholarPubMed
4.Henderson, B.W., and Dougherty, T.J.: How does photodynamic therapy work? Photochem. Photobiol. 55,145–157 (1992).CrossRefGoogle ScholarPubMed
5.Malatesti, N., Munitic, I., and Jurak, I.: Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents. Biophys. Rev. 9, 149–168 (2017).CrossRefGoogle ScholarPubMed
6.Huang, H., Song, W., Rieffel, J., and Lovell, J.F.: Emerging applications of porphyrins in photomedicine. Font. Phys. 3, 1–15 (2015).Google ScholarPubMed
7.Abrahamse, H., and Hamblin, M.: New photosensitizers for photodynamic therapy. Biochem. J. 473, 347–364 (2016).CrossRefGoogle ScholarPubMed
8.Debele, T.A., Peng, S., and Tsai, H.C.: Drug carrier for photodynamic cancer therapy. Int. J. Mol. Sci. 16, 22094–22136 (2015).CrossRefGoogle ScholarPubMed
9.Luksiene, Z.: Photodynamic therapy: mechanism of action and ways to improve the efficiency of treatment. Medicina (B. Aires) 39, 1137–1149 (2003).Google Scholar
10.Viana, O.S., Ribeiro, M.S., Rodas, A.C.D., Rebouças, J.S., Fontes, A., and Santos, B.S.: Comparative study on the efficiency of the photodynamic inactivation of Candida albicans using CdTe quantum dots, Zn(II) porphyrin and their conjugates as photosensitizers. Molecules 20, 8893–8912 (2015).CrossRefGoogle ScholarPubMed
11.Oluwole, D.O., and Nyokong, T.: Physicochemical behavior of nanohybrids of mono and tetra substituted carboxyphenoxy phthalocyanine covalently linked to GSH-CdTe/CdS/ZnS quantum dots. Polyhedron 87, 8–16 (2015).CrossRefGoogle Scholar
12.Frasco, M.F., Vamvakaki, V., and Chaniotakis, N.: Porphyrin decorated CdSe quantum dots for direct fluorescent sensing of metal ions. Nanopart. Res. 12, 1449–1458 (2010).CrossRefGoogle Scholar
13.Rotomskis, R. and Streckyte, G.: In Quantum Dots in PDT, Imaging in Photodynamic Therapy, edited by Hamblin, M.R., and Huange, Y. (Taylor and Francis, London, New York, 2017), pp. 183–210.CrossRefGoogle Scholar
14.Parani, S., Bupesh, G., Manikandan, E., Pandian, K., and Oluwafemi, O.S.: Facile synthesis of mercaptosuccinic acid-capped CdTe/CdS/ZnS core/double shell quantum dots with improved cell viability on different cancer cells and normal cells. J. Nanopart. Res. 18, 347 (2016).CrossRefGoogle Scholar
15.Kang, X., Yang, Y., Huang, L., Tao, Y., Wang, L., and Pan, D.: Large-scale synthesis of water-soluble CuInSe2/ZnS and AgInSe2/ZnS core/shell quantum dots. Green Chem. 17, 4482–4488 (2015).CrossRefGoogle Scholar
16.Tsolekile, N., Parani, S., Matoetoe, M.C., Songca, S.P., and Oluwafemi, O.S.: Evolution of ternary I–III–VI QDs: synthesis, characterization and application. Nano-Struct. Nano-Objects 12, 46–56 (2017).CrossRefGoogle Scholar
17.Neela Mohan, C., Renuga, V., and Manikandan, A.: Influence of silver precursor concentration on structural, optical and morphological properties of Cu1-xAgxInS2 semiconductor nanocrystals. J. Alloys Compd.729, 407–417 (2017).CrossRefGoogle Scholar
18.Chen, Y., Li, S., Huang, L., and Pan, D.: Low-cost and gram-scale synthesis of water soluble Cu–In–S/ZnS core/shell quantum dots in an electric pressure cooker. Nanoscale. 6, 1295–1298 (2014).CrossRefGoogle Scholar
19.Rojkiewicz, M., Kuś, P., Kozub, P., and Kempa, M.: The synthesis of new potential photosensitizers. Dye Pigment 99, 627–635 (2013).CrossRefGoogle Scholar
20.Adarsh, N., Avirah, R.R., and Ramaiah, D.: Tuning photosensitized singlet oxygen generation efficiency of novel Aza-BODIPY dyes. Org. Lett. 12, 5720–5723 (2010).CrossRefGoogle ScholarPubMed
21.Dayer, M.R., Movahedi, A.A.M. and Dayer, M.S.: Band Assignment in Hemoglobin Porphyrin Ring Spectrum: Using Four-Orbital Model of Gouterman. Protein Pept Lett 17, 473–479 (2010).CrossRefGoogle ScholarPubMed

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