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Multi-organ on a chip for personalized precision medicine

Published online by Cambridge University Press:  13 August 2018

Vivekanandan Palaninathan
Affiliation:
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Vimal Kumar
Affiliation:
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Toru Maekawa
Affiliation:
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Dorian Liepmann
Affiliation:
Department of Bioengineering, University of California, Berkeley, CA, USA
Ramasamy Paulmurugan
Affiliation:
Department of Radiology, Cellular Pathway Imaging Laboratory, Stanford University School of Medicine, 3155 Porter Drive, Suite 2236, Palo Alto, CA 94304, USA
Jairam R. Eswara
Affiliation:
Brigham and Women's Hospital, Division of Urology, 75 Francis Street, Boston, Massachusetts 02115, USA
Pulickel M. Ajayan
Affiliation:
Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA
Shine Augustine
Affiliation:
Department of Biotechnology, Delhi Technological University, Main Bawana Road, Delhi 110042, India
Bansi D. Malhotra
Affiliation:
Department of Biotechnology, Delhi Technological University, Main Bawana Road, Delhi 110042, India
Sowmya Viswanathan
Affiliation:
Newton-Wellesley Hospital, Newton, MA 02462, USA
Venkatesan Renugopalakrishnan
Affiliation:
Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
D. Sakthi Kumar
Affiliation:
Bio-Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan
Corresponding
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Abstract

The inefficiencies of the current pipeline from discovery to clinical approval of drugs demand a surrogate method to indicate adverse drug reactions, e.g. liver damage. Organ-on-chip (OOC) models would be an ideal, rapid, and human-specific alternate, which would render animal testing obsolete. The ground-breaking ability of OOCs and Multi-OOC constructs is the accurate simulation of the in vivo conditions of human organs leading to precise drug screens for cytotoxicity and/or drug efficacy at a faster pace and lesser cost. Here we discuss the innovation, architecture, and the progress of OOCs towards human body-on-a-chip.

Type
2D Nanomaterials for Healthcare and Lab-on-a-Chip Devices Prospective Articles
Copyright
Copyright © Materials Research Society 2018 

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Footnotes

This paper is dedicated to Suraj Renugopalakrishnan.

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