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Theranostic nanomaterials for image-guided gene therapy

Published online by Cambridge University Press:  10 January 2014

Seung Rim Hwang ,
Sook Hee Ku ,
Min Kyung Joo ,
Sun Hwa Kim  and
Ick Chan Kwon
Seung Rim Hwang
Affiliation:
College of Pharmacy, Chosun University, South Korea;srhwang@chosun.ac.kr
Sook Hee Ku
Affiliation:
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, South Korea;kusookhee@gmail.com
Min Kyung Joo
Affiliation:
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, South Korea;minkyjoo@gmail.com
Sun Hwa Kim
Affiliation:
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, South Korea;sunkim@kist.re.kr
Ick Chan Kwon
Affiliation:
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, South Korea;ikwon@kist.re.kr
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Abstract

Theranostics was proposed as a combined process of therapeutics and diagnostics methodology for increasing treatment efficacy and safety with simultaneous monitoring of the response to treatment. In the past two decades, nanotechnology has been the focus of developing strategies for drug delivery and imaging functions, and it has expanded to the design of multifunctional nanoparticles and the creation of “nanotheranostics” (i.e., theranostic nanomedicines). Nanotheranostics also shows potential in gene therapy; however, nanoparticle-mediated delivery of genes still faces major obstacles related to (1) the uptake by the reticuloendothelial system, (2) the ability to get across the target cell membranes through endocytosis, and (3) the ability to accumulate in organs with permeable vasculature. Here, we review the development and application of nanotheranostics, highlighting their relevance to gene therapy as well as molecular imaging.

Keywords

biomedicalbiomaterialnanoscale
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 1: Materials for Biological Modulation, Sensing, and Imaging , January 2014 , pp. 44 - 50
Copyright
Copyright © Materials Research Society 2014 

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