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Microvasculature: An essential component for organ-on-chip systems

  • Hyunjae Lee (a1), Minhwan Chung (a2) and Noo Li Jeon (a3)

Abstract

Improving the biological relevance of organs-on-chips is one of the main issues in biomedical engineering. The microvascular system is related to numerous biological phenomena throughout the life of organs. Although many in vitro microvascular systems have been developed, current organ-on-chip systems fail to fully integrate three-dimensional microvasculature, which results in decreased similarity of the systems with in vivo conditions. In this review, we propose that the microvascular system is an essential component for engineering organs-on-chips to achieve greater biological relevance. Various methods for engineering microvessels in vitro are reviewed, as well as recent representative efforts to engineer vascularized organs-on-chips. Material considerations for designing organs-on-chips are also reviewed.

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Corresponding author

*These authors have contributed equally.

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Microvasculature: An essential component for organ-on-chip systems

  • Hyunjae Lee (a1), Minhwan Chung (a2) and Noo Li Jeon (a3)

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