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Damage in electron cryomicroscopy: Lessons from biology for materials science

Published online by Cambridge University Press:  10 December 2019

C.J. Russo
Affiliation:
Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, UK; crusso@mrc-lmb.cam.ac.uk
R.F. Egerton
Affiliation:
University of Alberta, Canada; regerton@ualberta.ca
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Abstract

The recent success of electron cryomicroscopy in biology has drawn the attention of the materials science community, which is starting to employ similar techniques for imaging a wide variety of nonbiological specimens. This article reviews the theory and practical implications of radiation damage in electron microscopy, and then considers how electron cryomicroscopy techniques may be applied to other radiation-sensitive specimens of interest to materials scientists. We also discuss aspects of radiation damage that warrant further study as instrumentation technology advances and consider new methods that might be useful in the future.

Type
Cryogenic Electron Microscopy in Materials Science
Copyright
Copyright © Materials Research Society 2019 

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